Inorganic calcium filled bacterial cellulose based hydrogel scaffold: novel biomaterial for bone tissue regeneration

被引：18

作者：

Basu, Probal ^{[1
]}

Saha, Nabanita ^{[1
]}

Saha, Petr ^{[1
]}

机构：

[1] Tomas Bata Univ Zlin, Ctr Polymer Syst, Univ Inst, Trida Tomase Bati 5678, Zlin 76001, Czech Republic

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2019年 / 68卷 / 1-3期

关键词：

Bacterial cellulose; bone regeneration; calcium phosphate; calcium carbonate; in vitro bio-mineralization; PVP-CMC HYDROGEL; ACID; BIOCOMPATIBILITY; HYDROXYAPATITE; BLEND; PH;

D O I：

10.1080/00914037.2018.1525733

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

This work emphasizes the structural, physio-chemical characterization and cell biological efficiency analysis of novel inorganic calcium (only calcium phosphate and in combination of calcium phosphate & CaCO3) filled bacterial cellulose (BC) based hydrogel scaffolds. FTIR and TG analysis indicates the presence of BC and inorganic calcium within the hydrogel scaffolds. SEM establishes the porous structures (50-200 mu m). Swelling study indicates significant swelling ability in both calcium phosphate filled and calcium phosphate & CaCO3 filled hydrogel scaffolds. Compressive strength (0.24-0.60 MPa) of the calcium filled hydrogel scaffolds are similar like trabecular bone. Significant cell viability (Lep-3) was further noticed until 72,120 and 168 h. [GRAPHICS] .

引用

页码：134 / 144

页数：11

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