An efficient synthetic route to carbocyclic enaminonitriles via Lewis acid catalysed domino-ring-opening-cyclisation (DROC) of donor-acceptor cyclopropanes with malononitrile

被引：41

作者：

Ghorai, Manas K. ^{[1
]}

Talukdar, Ranadeep ^{[1
]}

Tiwari, Deo Prakash ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 74期

关键词：

ENANTIOSELECTIVE SYNTHESIS; BETA-ENAMINONITRILES; ACTIVATED AZIRIDINES; 3+2 CYCLOADDITION; HETEROCYCLIC SYNTHESIS; BUILDING-BLOCKS; DERIVATIVES; CONSTRUCTION; ANNULATIONS; INHIBITORS;

D O I：

10.1039/c3cc44533j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient strategy for the synthesis of functionalised carbocyclic enaminonitriles in excellent yields has been described. The reaction utilises Yb(OTf)(3) catalysed C-C bond cleavage and two simultaneous C-C bond formations of donor-acceptor (DA)-cyclopr-opanes with malononitrile anions in a domino fashion.

引用

页码：8205 / 8207

页数：3

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