Uniform Polypyrrole Nanoparticles with High Photothermal Conversion Efficiency for Photothermal Ablation of Cancer Cells

被引:707
作者
Zha, Zhengbao [1 ]
Yue, Xiuli [2 ]
Ren, Qiushi [3 ]
Dai, Zhifei [1 ,3 ]
机构
[1] Harbin Inst Technol, State Key Lab Urban Water Resources & Environm, Sch Life Sci & Technol, Harbin 150080, Peoples R China
[2] Harbin Inst Technol, State Key Lab Urban Water Resources & Environm, Harbin 150080, Peoples R China
[3] Peking Univ, Dept Biomed Engneering, Coll Engn, Beijing 100871, Peoples R China
关键词
polypyrrole nanoparticles; photothermal ablation; dispersion polymerization; IN-VIVO; GOLD NANORODS; INDOCYANINE GREEN; CELLULAR UPTAKE; THERAPY; NANOCRYSTALS; AGENT; LASER; BIOCOMPATIBILITY; CYTOTOXICITY;
D O I
10.1002/adma.201202211
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Uniform polypyrrole (PPy) nanoparticles are fabricated from a facile one-step aqueous dispersion polymerization. Owing to their high photothermal conversion efficiency and photostability compared with the well-known Au nanorods, as well as their good colloidal stability and biocompatibility, the resulting PPy nanoparticles can used as a novel promising photothermal ablation coupling agent for targeted treatment of cancer. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:777 / 782
页数:6
相关论文
共 49 条
[1]   Cellular Uptake and Cytotoxicity of Gold Nanorods: Molecular Origin of Cytotoxicity and Surface Effects [J].
Alkilany, Alaaldin M. ;
Nagaria, Pratik K. ;
Hexel, Cole R. ;
Shaw, Timothy J. ;
Murphy, Catherine J. ;
Wyatt, Michael D. .
SMALL, 2009, 5 (06) :701-708
[2]  
ARMES SP, 1987, J CHEM SOC CHEM COMM, P288
[3]   Polypyrrole Nanoparticles: A Potential Optical Coherence Tomography Contrast Agent for Cancer Imaging [J].
Au, Kin Man ;
Lu, Zenghai ;
Matcher, Stephen J. ;
Armes, Steven P. .
ADVANCED MATERIALS, 2011, 23 (48) :5792-+
[4]   ELECTRICALLY CONDUCTING COMPOSITES OF COLLOIDAL POLYPYRROLE AND METHYLCELLULOSE [J].
BJORKLUND, RB ;
LIEDBERG, B .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1986, (16) :1293-1295
[5]   A NONISOTOPIC, HIGHLY SENSITIVE, FLUOROMETRIC, CELL-CELL ADHESION MICROPLATE ASSAY USING CALCEIN AM-LABELED LYMPHOCYTES [J].
BRAUTBOUCHER, F ;
PICHON, J ;
RAT, P ;
ADOLPHE, M ;
AUBERY, M ;
FONT, J .
JOURNAL OF IMMUNOLOGICAL METHODS, 1995, 178 (01) :41-51
[6]   Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells [J].
Chen, Jingyi ;
Wang, Danling ;
Xi, Jiefeng ;
Au, Leslie ;
Siekkinen, Andy ;
Warsen, Addie ;
Li, Zhi-Yuan ;
Zhang, Hui ;
Xia, Younan ;
Li, Xingde .
NANO LETTERS, 2007, 7 (05) :1318-1322
[7]   Gold Nanocages as Photothermal Transducers for Cancer Treatment [J].
Chen, Jingyi ;
Glaus, Charles ;
Laforest, Richard ;
Zhang, Qiang ;
Yang, Miaoxian ;
Gidding, Michael ;
Welch, Michael J. ;
Xia, Younan .
SMALL, 2010, 6 (07) :811-817
[8]  
Chen WR, 1996, CANCER LETT, V98, P169
[9]  
Cheng L, 2012, ACS NANO, V6, P5605, DOI [10.1021/nn304719q, 10.1021/nn301539m]
[10]   Renal clearance of quantum dots [J].
Choi, Hak Soo ;
Liu, Wenhao ;
Misra, Preeti ;
Tanaka, Eiichi ;
Zimmer, John P. ;
Ipe, Binil Itty ;
Bawendi, Moungi G. ;
Frangioni, John V. .
NATURE BIOTECHNOLOGY, 2007, 25 (10) :1165-1170