Association of IL-18 gene polymorphism (-137C) with arthritis manifestations in SLE: combined effect with IFN gamma gene polymorphism (+874A)

被引：23

作者：

Hirankarn, Nattiya ^{[1
]}

Tangwattanachuleeporn, Marut ^{[2
]}

Wongpiyabovorn, Jongkonnee ^{[1
]}

Wongchinsri, Jeerapat ^{[3
]}

Avihingsanon, Yingyos ^{[4
]}

机构：

[1] Chulalongkorn Univ, Fac Med, Dept Microbiol, Lupas Res Unit, Bangkok 10330, Thailand

[2] Burapha Univ, Fac Sci, Dept Med Sci, Chon Buri, Thailand

[3] Nopparat Rajathanee Hosp, Dept Med, Bangkok, Thailand

[4] Chulalongkorn Univ, Fac Med, Dept Med, Lupas Res Unit, Bangkok 10330, Thailand

来源：

CLINICAL RHEUMATOLOGY | 2009年 / 28卷 / 02期

关键词：

Gene polymorphism; Interleukin; 12; 18; SLE; SYSTEMIC-LUPUS-ERYTHEMATOSUS; DISEASE-ACTIVITY; INTERLEUKIN-18; MICE; TH1; NEPHRITIS; GENOTYPE; PROMOTER; EXPRESSION; RESPONSES;

D O I：

10.1007/s10067-008-1036-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We analyzed the association between single nucleotide polymorphisms in IL-12 and IL-18 genes in disease susceptibility and severity of SLE in Thais. A weak association was observed between A allele of the IL-12 gene at the 3' untranslated region in SLE patients with proteinuria (OR = 1.89, 95% CI = 1.05-3.40, P = 0.02, Pc = 0.06). In addition, we found a significant association between C allele of IL-18 (-137) with arthritis (OR = 6.88, 95% CI = 1.54-42.93, P = 0.003, Pc = 0.009). The presence of one C allele (C/C+C/G) was associated with significant OR of 8.72 (95% CI = 1.83-56.71, P = 0.001, Pc = 0.003). Interestingly, we found the combined effect between the G/C genotype of IL-18 (-137) and the A/A genotype of IFNG (+874) gene causing susceptibility of arthritis in SLE patients (OR = 13.22, 95% CI = 1.56-291.66, P = 0.004).

引用

页码：219 / 223

页数：5