Immunology and Clinical Manifestations of Non-Clonal Mast Cell Activation Syndrome

被引：34

作者：

Cardet, Juan-Carlos ^{[1
,2
]}

Castells, Mariana C. ^{[1
,2
]}

Hamilton, Matthew J. ^{[2
,3
]}

机构：

[1] Brigham & Womens Hosp, Div Rheumatol Immunol & Allergy, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA

来源：

CURRENT ALLERGY AND ASTHMA REPORTS | 2013年 / 13卷 / 01期

关键词：

Mast cell activation; Non-clonal mast cell activation syndrome; Tryptase; Prostaglandin; Histamine; cKIT; Flushing; Anaphylaxis; Antihistamines; Immunology; BLOOD MONONUCLEAR-CELLS; SYSTEMIC MASTOCYTOSIS; TRYPTASE LEVELS; C-KIT; PROSTAGLANDIN D-2; TYROSINE KINASE; SPANISH NETWORK; BONE-MARROW; ANAPHYLAXIS; DISORDERS;

D O I：

10.1007/s11882-012-0326-8

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

There is a spectrum of disorders that clinically manifest as a result of mast cell activation. A non-clonal form has emerged in the literature where many of the clinical features of systemic mastocytosis are shared despite having a distinct mast cell biology. In this review, we summarize key features of the science behind mast cell activation relevant to what is now known as non-clonal mast cell activation syndrome (nc-MCAS). We highlight the clinical manifestations of nc-MCAS with a focus on diagnosis and treatment.

引用

页码：10 / 18

页数：9

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