Principles of Good Clinical Trial Design

Clinical trials are a fundamental component of medical research and serve as the main route to obtain evidence of the safety and efficacy of treatment before its approval. A trial's ability to provide the intended evidence hinges on appropriate design, background knowledge, trial rationale to sample size, and interim monitoring rules. In this article, we present some general design principles for investigators and their research teams to consider when planning to conduct a trial. (C) 2020 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.