共 58 条
Experimentally reduced insulin/IGF-1 signaling in adulthood extends lifespan of parents and improves Darwinian fitness of their offspring
被引:29
作者:
Lind, Martin, I
[1
]
Ravindran, Sanjana
[1
]
Sekajova, Zuzana
[1
]
Carlsson, Hanne
[1
,2
]
Hinas, Andrea
[3
]
Maklakov, Alexei A.
[1
,2
]
机构:
[1] Uppsala Univ, Dept Ecol & Genet, Anim Ecol, S-75236 Uppsala, Sweden
[2] Univ East Anglia, Sch Biol Sci, Norwich NR4 7TJ, Norfolk, England
[3] Uppsala Univ, Dept Cell & Mol Biol, S-75124 Uppsala, Sweden
基金:
欧洲研究理事会;
瑞典研究理事会;
关键词:
Ageing;
antagonistic pleiotropy;
functional trade-offs;
hyperfunction;
IIS signaling;
parental effects;
senescence;
NATURAL-POPULATIONS;
SENESCENCE;
EVOLUTION;
LONGEVITY;
MUTATION;
SEX;
REPRODUCTION;
MAINTENANCE;
MECHANISMS;
SELECTION;
D O I:
10.1002/evl3.108
中图分类号:
Q [生物科学];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Classical theory maintains that ageing evolves via energy trade-offs between reproduction and survival leading to accumulation of unrepaired cellular damage with age. In contrast, the emerging new theory postulates that ageing evolves because of deleterious late-life hyper-function of reproduction-promoting genes leading to excessive biosynthesis in late-life. The hyper-function theory uniquely predicts that optimizing nutrient-sensing molecular signaling in adulthood can simultaneously postpone ageing and increase Darwinian fitness. Here, we show that reducing evolutionarily conserved insulin/IGF-1 nutrient-sensing signaling via daf-2 RNA interference (RNAi) fulfils this prediction in Caenorhabditis elegans nematodes. Long-lived daf-2 RNAi parents showed normal fecundity as self-fertilizing hermaphrodites and improved late-life reproduction when mated to males. Remarkably, the offspring of daf-2 RNAi parents had higher Darwinian fitness across three different genotypes. Thus, reduced nutrient-sensing signaling in adulthood improves both parental longevity and offspring fitness supporting the emerging view that suboptimal gene expression in late-life lies at the heart of ageing.
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页码:207 / 216
页数:10
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