The spread of Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) in North America: A phylogeographic approach

被引：49

作者：

Shi, Mang ^{[1
,2
]}

Lemey, Philippe ^{[3
]}

Brar, Manreetpal Singh ^{[4
]}

Suchard, Marc A. ^{[5
,6
,7
]}

Murtaugh, Michael P. ^{[8
]}

Carman, Susy ^{[9
]}

D'Allaire, Sylvie ^{[10
]}

Delisle, Benjamin ^{[10
]}

Lambert, Marie-Eve ^{[10
]}

Gagnon, Carl A. ^{[10
]}

Ge, Li ^{[9
]}

Qu, Yihan ^{[11
]}

Yoo, Dongwan ^{[12
]}

Holmes, Edward C. ^{[1
,2
,13
]}

Leung, Frederick Chi-Ching ^{[4
,14
]}

机构：

[1] Univ Sydney, Sch Biol Sci, Sydney Emerging Infect & Biosecur Inst, Sydney, NSW 2006, Australia

[2] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia

[3] Katholieke Univ Leuven, Rega Inst, Dept Microbiol & Immunol, B-3000 Louvain, Belgium

[4] Univ Hong Kong, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China

[5] Univ Calif Los Angeles, Jonathan & Karin Fielding Sch Publ Hlth, Dept Biostat, Los Angeles, CA USA

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Biomath, Los Angeles, CA 90095 USA

[7] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA

[8] Univ Minnesota, Dept Vet & Biomed Sci, St Paul, MN 55108 USA

[9] Univ Guelph, Lab Serv Div, Hlth Anim Lab, Guelph, ON N1H 6R8, Canada

[10] Univ Montreal, Fac Med Vet, St Hyacinthe, PQ J2S 7C6, Canada

[11] Univ Sydney, Fac Agr & Environm, Sydney, NSW 2006, Australia

[12] Univ Illinois, Coll Vet Med, Urbana, IL 61801 USA

[13] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA

[14] Nanjing Agr Univ, Bioinformat Ctr, Nanjing, Jiangsu, Peoples R China

来源：

VIROLOGY | 2013年 / 447卷 / 1-2期

基金：

欧洲研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

Phylogeography; PRRSV; Evolution; Recombination; Molecular epidemiology; RECOMBINATION; SEQUENCES; EVOLUTIONARY; PHYLOGENIES; MODELS;

D O I：

10.1016/j.virol.2013.08.028

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The emergence and spread of Type 2 Porcine Reproductive and Respiratory Syndrome virus (Type 2 PRRSV) in North America is heavily influenced by the multiple site production system used in the hog industry. However, it is unclear how anthropogenic factors such has this have shaped the current spatial distribution of PRRSV genotypes. We employed Bayesian phylogeographic analyses of 7040 ORF5 sequences to reveal the recent geographical spread of Type 2 PRRSV in North America. The directions and intensities in our inferred virus traffic network closely mirror the hog transportation. Most notably, we reveal multiple viral introductions from Canada into the United States causing a major shift in virus genetic composition in the Midwest USA that went unnoticed by the regular surveillance and field epidemiological studies. Overall, these findings provide important insights into the dynamics of Type 2 PRRSV evolution and spread that will facilitate programs for control and prevention. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：146 / 154

页数：9

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