Segmental bone defect repair using sintered, porous ceramics

被引：2

作者：

Fredericks, DC ^{[1
]}

Bobst, JA

Petersen, EB

Nepola, JV

Heckendorf, B

Norberg, B

Ko, Y

Cassidy, JJ

机构：

[1] Univ Iowa, Iowa City, IA 52242 USA

[2] CERAbio LLC, Prescott, WI USA

来源：

BIOCERAMICS 14 | 2002年 / 218-2卷

关键词：

porous ceramics; bone substitutes; rabbits; hydroxyapatite; beta-tricalcium; phosphate; alumina;

D O I：

10.4028/www.scientific.net/KEM.218-220.409

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The use of sintered, porous ceramics as alternatives to autograft was studied in a rabbit segmental defect model. One hundred and eight rabbits were entered into the study. A one centimeter mid-diaphyseal segmental defect was created and stabilized with an external fixator. The defect was filled with a porous sintered ceramic, autograft or left open. Animals were radiographed weekly and sacrificed at 6 or 8 weeks post-operatively. Torsional strengths of hydroxyapatite, tricalcium phosphate, and autograft groups were as strong as or stronger than there internal control limbs at 6 weeks post surgery, where as the open control group was 50% of its internal control limb. The alumina group at 6 weeks was 84% of normal. At 8 weeks, all ceramic groups had significantly higher torsional strengths than internal controls. The sintered, porous ceramics used in this study are good alternatives to autograft in repair of diaphyseal segmental defects.

引用

页码：409 / 412

页数：4