Abnormal accumulation of G2/M-phase cells from LEC strain rats after X-irradiation at S phase

被引：3

作者：

Hayashi, M ^{[1
]}

Kuzumi, T

Arai, S

Okui, T

机构：

[1] Rakuno Gakuen Univ, Fac Vet Med, Dept Vet Radiol, Ebetsu, Hokkaido 0698501, Japan

[2] Hokkaido Inst Publ Hlth, Sapporo, Hokkaido 0600819, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 1999年 / 61卷 / 08期

关键词：

G2/M accumulation; LEC strain rat; X-irradiation;

D O I：

10.1292/jvms.61.975

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The effect of X-irradiation on the progression of the cell cycle in cell lines from LEC and WKAH rats was investigated by a flow cytometer. When the cells were exposed to 5 Gy of X-rays at S phase, the proportion of S-phase cells in both cell populations decreased with incubation time and that of G2/M-phase cells was approximately 80% at 6 hr post-irradiation. At 12 hr post-irradiation, approximately 45% of the WKAH rat cells appeared in the G1 phase. However, 80-90% of LEC rat cells remained in the G2/M phase and less than 5% in the G1 phase during 6-12 hr post-irradiation. Thus, the LEC rat cells irradiated at S phase remained in the G2/M phase for at least 6 hr longer than did the WKAH rat cells.

引用

页码：975 / 978

页数：4

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