Radical Route for the Alkylation of Purine Nucleosides at C6 via Minisci Reaction

被引：88

作者：

Xia, Ran ^{[1
,2
]}

Xie, Ming-Sheng ^{[2
]}

Niu, Hong-Ying ^{[2
]}

Qu, Gui-Rong ^{[1
,2
]}

Guo, Hai-Ming ^{[1
,2
]}

机构：

[1] Henan Normal Univ, Sch Environm, Xinxiang 453007, Henan Province, Peoples R China

[2] Henan Normal Univ, Sch Chem & Chem Engn, Key Lab Green Chem Media & React,Minist Educ, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Xinxiang 453007, Henan Province, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 02期

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

CROSS-COUPLING REACTIONS; CYTOSTATIC 6-ARYLPURINE NUCLEOSIDES; CYCLIN-DEPENDENT KINASE-1; EFFICIENT SYNTHESIS; BIOLOGICAL-ACTIVITY; GRIGNARD-REAGENTS; BOND FORMATION; HETEROCYCLES; BASES; DERIVATIVES;

D O I：

10.1021/ol4033336

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly regioselective Minisci reaction with the decarboxylative alkylation of purine nucleosides under mild conditions was developed. With 5 mol % AgNO3 as a catalyst and (NH4)(2)S2O8 as an oxidant, a series of purine nucleosides including ribosyl, deoxyribosyl, arabinosyl purine nucleosides worked well with primary, secondary, and tertiary aliphatic carboxylic acids.

引用

收藏

页码：444 / 447

页数：4

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