Preeclampsia-Like Symptoms Induced in Mice by Fetoplacental Expression of STOX1 Are Reversed by Aspirin Treatment

被引：96

作者：

Doridot, Ludivine ^{[1
,2
,3
]}

Passet, Bruno ^{[4
]}

Mehats, Celine ^{[1
,2
,3
]}

Rigourd, Virginie ^{[1
,2
,3
,5
]}

Barbaux, Sandrine ^{[1
,2
,3
]}

Ducat, Aurelien ^{[1
,2
,3
]}

Mondon, Francoise ^{[1
,2
,3
]}

Vilotte, Marthe ^{[4
]}

Castille, Johann ^{[4
]}

Breuiller-Fouche, Michelle ^{[1
,2
,3
]}

Daniel, Nathalie ^{[6
]}

le Provost, Fabienne ^{[4
]}

Bauchet, Anne-Laure ^{[7
]}

Baudrie, Veronique ^{[8
]}

Hertig, Alexandre ^{[9
]}

Buffat, Christophe ^{[10
,11
]}

Simeoni, Umberto ^{[12
]}

Germain, Guy ^{[7
]}

Vilotte, Jean-Luc ^{[4
]}

Vaiman, Daniel ^{[1
,2
,3
]}

机构：

[1] Inst Cochin Genet Mol, INSERM, U1016, F-75014 Paris, France

[2] CNRS, UMRS 8104, Paris, France

[3] Univ Paris 05, Paris, France

[4] INRA, Genet Anim & Biol Integrat UMR1313, Jouy En Josas, France

[5] Lactarium Ile France, Inst Puericulture & Perinatal, Paris, France

[6] INRA, UMR Biol Dev & Reprod 1198, Jouy En Josas, France

[7] CEA, I2BM, MIRCen, Fontenay Aux Roses, France

[8] Hop Georges Pompidou, INSERM, U970, Paris Ctr Rech Cardiovasc, Paris, France

[9] INSERM, UMR S702, Paris, France

[10] Aix Marseille Univ, URMIT, UMR 6236, Marseille, France

[11] Hop Conception, APHM, Mol Biol Lab, Marseille, France

[12] Hop Conception, APHM, Serv Med Neonatale, Marseille, France

来源：

HYPERTENSION | 2013年 / 61卷 / 03期

关键词：

hypertension; mouse model; preeclampsia; proteinuria; STOX1; MOUSE MODEL; HYPERTENSION; PREVENTION; DEFICIENCY; GESTATION; CELLS;

D O I：

10.1161/HYPERTENSIONAHA.111.202994

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Preeclampsia (PE) is a common human-specific pregnancy disorder defined by hypertension and proteinuria during gestation and responsible for maternal and fetal morbimortality. STOX1, encoding a transcription factor, was the first gene associated with PE as identified by positional cloning approaches. Its overexpression in choriocarcinoma cells mimics the transcriptional consequences of PE in the human placenta. Here, we created transgenic mouse strains overexpressing human STOX1. Wild-type female mice crossed with transgenic male mice reproduce accurately the symptoms of severe PE: gestational hypertension, proteinuria, and elevated plasma levels of soluble fms-like tyrosine kinase 1 and soluble endoglin. Placental and kidney histology were altered. Symptoms were prevented or alleviated by aspirin treatment. STOX1-overexpressing mice constitute a unique model for studying PE, allow testing therapeutic approaches, and assessing the long-term effects of the preeclamptic syndrome. (Hypertension. 2013;61:662-668.) circle Online Data Supplement

引用

页码：662 / +

页数：17

共 38 条

[1] A New Mouse Model to Explore Therapies for Preeclampsia [J].