Estrogen receptor gene polymorphisms are associated with recurrence of endometriosis

被引：64

作者：

Luisi, S

Galleri, L

Marini, F

Ambrosini, G

Brandi, ML

Petraglia, F

机构：

[1] Univ Siena, Policlin S Maria Scotte, Dept Pediat Gynecol & Reprod Med, Chair Obstet & Gynecol, I-53100 Siena, Italy

[2] Univ Florence, Dept Clin Pathophysiol, Florence, Italy

[3] Univ Padua, Dept Gynecol Sci & Reprod Med, Padua, Italy

来源：

FERTILITY AND STERILITY | 2006年 / 85卷 / 03期

关键词：

D O I：

10.1016/j.fertnstert.2005.08.038

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The presence of gene polymorphisms of the estrogen receptors ER alpha (PvuII and XbaI) and ER beta (AluI) in 61 women with endometriosis was investigated. A statistically significant correlation between PvuII ER alpha gene polymorphism (PvuII), both in homozygosity (PP) and in heterozygosity (Pp), and a recurrence of endometriosis was found. In conclusion, women affected by endometriosis with the ER alpha polymorphic allele, even if heterozygous, have a worse prognosis, and these results suggest that the ER alpha gene polymorphisms. may be included among the genetic risk factors for endometriosis.

引用

页码：764 / 766

页数：3

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