Additional Diagnostic Yield of Adding Serology to PCR in Diagnosing Viral Acute Respiratory Infections in Kenyan Patients 5 Years of Age and Older

被引：20

作者：

Feikin, Daniel R. ^{[1
]}

Njenga, M. Kariuki ^{[1
]}

Bigogo, Godfrey ^{[1
]}

Aura, Barrack ^{[1
]}

Gikunju, Stella ^{[1
]}

Balish, Amanda ^{[2
]}

Katz, Mark A. ^{[1
]}

Erdman, Dean ^{[2
]}

Breiman, Robert F. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent Publ Hlth & Res Collabo, Kenya Med Res Inst, Kisumu, Kenya

[2] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2013年 / 20卷 / 01期

关键词：

COMMUNITY-ACQUIRED PNEUMONIA; REQUIRING HOSPITALIZATION; ADULTS; ETIOLOGY; THAILAND; VIRUS;

D O I：

10.1128/CVI.00325-12

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of serology in the setting of PCR-based diagnosis of acute respiratory infections (ARIs) is unclear. We found that acute- and convalescent-phase paired-sample serologic testing increased the diagnostic yield of naso/oropharyngeal swabs for influenza virus, respiratory syncytial virus (RSV), human metapneumovirus, adenovirus, and parainfluenza viruses beyond PCR by 0.4% to 10.7%. Although still limited for clinical use, serology, along with PCR, can maximize etiologic diagnosis in epidemiologic studies.

引用

页码：113 / 114

页数：2

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