Viral interleukin-10 in chronic active Epstein-Barr virus infection

被引:62
作者
Kanegane, H
Wakiguchi, H
Kanegane, C
Kurashige, T
Tosato, G
机构
[1] FDA,CTR BIOL EVALUAT & RES,DHP,ROCKVILLE,MD 20852
[2] KOCHI MED SCH,DEPT PEDIAT,NANKO KU,KOCHI,JAPAN
关键词
D O I
10.1086/517260
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Viral interleukin-10 (IL-10), a product of the Epstein-Barr virus (EBV) replication gene BCRF1, shares extensive structural and functional similarity with the human cytokine IL-10. Both viral and human IL-10 inhibit T cell growth and interferon-gamma production, with two ELISAs, one that recognized both human and viral (total) IL-10 and the other specific for viral IL-10, IL-10 was measured in serum or plasma from 34 patients with chronic active EBV infection (CAEBV) and from 15 healthy controls. Of the patients, 56% had measurable total IL-10 and 29% had measurable viral IL-10. In contrast, total IL-10 was detectable in only 2 of 15 controls and viral IL-10 was undetectable. Thus, many patients with CAEBV have abnormally high levels of circulating IL-10 that may contribute to disease pathogenesis by inhibiting host immunity.
引用
收藏
页码:254 / 257
页数:4
相关论文
共 15 条
[1]  
FOX RI, 1994, J IMMUNOL, V152, P5532
[2]   CHRONIC ACTIVE EPSTEIN-BARR-VIRUS INFECTION IN CHILDREN IN JAPAN [J].
ISHIHARA, S ;
OKADA, S ;
WAKIGUCHI, H ;
KURASHIGE, T ;
MORISHIMA, T ;
KAWAHA, K .
ACTA PAEDIATRICA, 1995, 84 (11) :1271-1275
[3]  
KIEFF E, 1990, VIROLOGY, P1889
[4]   INTERLEUKIN-10 PRODUCTION DURING SEPTICEMIA [J].
MARCHANT, A ;
DEVIERE, J ;
BYL, B ;
DEGROOTE, D ;
VINCENT, JL ;
GOLDMAN, M .
LANCET, 1994, 343 (8899) :707-708
[5]  
Masucci Maria G., 1994, Trends in Microbiology, V2, P125, DOI 10.1016/0966-842X(94)90599-1
[6]  
MILLER G, 1990, VIROLOGY, P1921
[7]   VIRAL INTERLEUKIN-10 IS CRITICAL FOR THE INDUCTION OF B-CELL GROWTH TRANSFORMATION BY EPSTEIN-BARR-VIRUS [J].
MIYAZAKI, I ;
CHEUNG, RK ;
DOSCH, HM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) :439-447
[8]  
MOORE KW, 1993, ANNU REV IMMUNOL, V11, P165, DOI 10.1146/annurev.iy.11.040193.001121
[9]   Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI [J].
Moore, Kevin W. ;
Vieira, Paulo ;
Fiorentino, David F. ;
Trounstine, Mary L. ;
Khan, Tariq A. ;
Mosmann, Timothy R. .
JOURNAL OF IMMUNOLOGY, 2012, 189 (05) :1230-1234
[10]   SEVERE CHRONIC ACTIVE EPSTEIN-BARR-VIRUS INFECTION SYNDROME [J].
OKANO, M ;
MATSUMOTO, S ;
OSATO, T ;
SAKIYAMA, Y ;
THIELE, GM ;
PURTILO, DT .
CLINICAL MICROBIOLOGY REVIEWS, 1991, 4 (01) :129-135