Combined Multimodal Computed Tomography Score Correlates With Futile Recanalization After Thrombectomy in Patients With Acute Stroke

被引：59

作者：

Espinosa de Rueda, Mariano ^{[1
]}

Parrilla, Guillermo ^{[1
,2
]}

Manzano-Fernandez, Sergio ^{[3
]}

Garcia-Villalba, Blanca ^{[1
]}

Zamarro, Joaquin ^{[1
]}

Hernandez-Fernandez, Francisco ^{[4
]}

Sanchez-Vizcaino, Cristina ^{[2
]}

Carreon, Ester ^{[2
]}

Morales, Ana ^{[2
]}

Moreno, Antonio ^{[1
]}

机构：

[1] Hosp Clin Univ Virgen de la Arrixaca, Serv Intervent Neuroradiol, Murcia 30120, Spain

[2] Hosp Clin Univ Virgen de la Arrixaca, Serv Neurol, Murcia 30120, Spain

[3] Hosp Clin Univ Virgen de la Arrixaca, Serv Cardiol, Murcia 30120, Spain

[4] Hosp Gen Univ Albacete, Serv Neurol, Albacete, Spain

来源：

STROKE | 2015年 / 46卷 / 09期

关键词：

angiography; multimodal imaging; stroke; thrombectomy; tomography; ACUTE ISCHEMIC-STROKE; TISSUE-PLASMINOGEN ACTIVATOR; FINAL INFARCT EXTENT; CT ANGIOGRAPHY; ENDOVASCULAR TREATMENT; IMAGING SELECTION; PERFUSION; THERAPY; TRIAL; THROMBOLYSIS;

D O I：

10.1161/STROKEAHA.114.008598

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-Futile recanalization after acute ischemic stroke occurs in almost half of the patients despite optimal angiographic results. Multimodal neuroimaging may help to improve patient's selection but is still dismissed by many interventionalists. Our aim was to evaluate the accuracy of each parameter of multimodal computed tomography (CT) and their combination for predicting futile recanalization after successful thrombectomy. Methods-We retrospectively reviewed a cohort of consecutive patients with anterior circulation stroke, fully assessable multimodal CT, and successful recanalization. Nonenhanced CT, CT angiography source images, cerebral blood volume (CBV), cerebral blood flow (CBF), and mismatch CBV-CBF maps were studied by Alberta Stroke Program Early CT Score (ASPECTS); collaterals on CT angiography were graded as poor or good (<= 50% or >50% of the middle cerebral artery territory). Futile recanalization was defined as modified Rankin Scale score >2 at 3 months despite successful recanalization. Results-One hundred fifty patients were included and 57% of them had futile recanalization. They had lower ASPECTS on nonenhanced CT, CT angiography source images, CBV, CBF, and mismatch CBV-CBF and presented more frequently poor collaterals (all P<0.001). Among them, CBV showed the highest area under the curve (0.83; 95% confidence interval, 0.76-0.88). In multivariate analyses, CT angiography source images <= 5 (odds ratio, 5.1; 95% confidence interval, 1.2-21.9), CBV <= 6 (odds ratio, 3.5; 95% confidence interval, 1.2-9.7), and poor collaterals (odds ratio, 8.6; 95% confidence interval, 1.8-41.7) were independent predictors of futile recanalization. A combined score of these 3 parameters added complementary information: 57% of the patients with score-1, 89% with score-2, and 100% with score-3 had futile recanalization. Reclassification analyses indicated that this score improved prediction of futile recanalization. Conclusions-In this population, a combined multimodal CT score predicted futile recanalization.

引用

页码：2517 / 2522

页数：6

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