The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities

被引：1

作者：

Ng, Jane W. Y. ^{[1
,2
]}

Barrett, Laura M. ^{[1
]}

Wong, Andrew ^{[4
]}

Kuh, Diana ^{[1
]}

Smith, George Davey ^{[3
]}

Relton, Caroline L. ^{[1
]}

机构：

[1] Newcastle Univ, Inst Med Genet, Newcastle NE1 3BZ, England

[2] Univ British Columbia, Clinician Investigator Program, Vancouver, BC V6Z 1Y6, Canada

[3] Univ Bristol, Sch Social & Community Med, MRC Ctr Causal Anal Translat Epidemiol CAiTE, Bristol BS8 2BN, Avon, England

[4] MRC Unit Lifelong Hlth & Aging, London WC1B 5JU, England

来源：

GENOME BIOLOGY | 2012年 / 13卷 / 06期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

Epigenomics; DNA methylation; life course; longitudinal studies; GENE PROMOTER METHYLATION; GENOMIC DNA METHYLATION; MENDELIAN RANDOMIZATION; CARDIOVASCULAR-DISEASE; COLORECTAL-CANCER; PRENATAL EXPOSURE; SMOKE EXPOSURE; GASTRIC-CANCER; BLOOD DNA; EXPRESSION;

D O I：

10.1186/gb4029

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Longitudinal cohort studies are ideal for investigating how epigenetic patterns change over time and relate to changing exposure patterns and the development of disease. We highlight the challenges and opportunities in this approach.

引用

页数：13

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