No association between the alpha 1-antichymotrypsin A allele and Alzheimer's disease

被引：33
作者：
Murphy, GM
Sullivan, EV
GallagherThompson, D
Thompson, LW
vanDuijn, CM
Forno, LS
Ellis, WG
Jagust, WJ
Yesavage, J
Tinklenberg, JR
机构：
[1] STANFORD UNIV,SCH MED,DEPT MED,STANFORD,CA 94305
[2] VET AFFAIRS PALO ALTO HLTH CARE SYST,DEPT NEUROPATHOL,PALO ALTO,CA
[3] ERASMUS UNIV ROTTERDAM,SCH MED,DEPT EPIDEMIOL & BIOSTAT,ROTTERDAM,NETHERLANDS
[4] UNIV CALIF DAVIS,DEPT PATHOL,DAVIS,CA 95616
[5] UNIV CALIF DAVIS,DEPT NEUROL,DAVIS,CA 95616
来源：
NEUROLOGY | 1997年 / 48卷 / 05期
关键词：
D O I：
10.1212/WNL.48.5.1313
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The alpha 1-antichymotrypsin (ACT) A allele was recently associated with Alzheimer's disease (AD), and the ACT AA genotype was reported to be more frequent in AD subjects with the apolipoprotein E (APOE) epsilon 4 allele. We examined ACT and APOE genotypes in a sample of 160 subjects with probable AD and in 102 elderly control subjects. ACT A. allele frequencies were similar in AD subjects (0.503) and elderly controls (0.519). In addition, we found no evidence that in AD the AA genotype is more frequent in subjects with the APOE E4 allele than in those without it. Our results do not support an association between the ACT A allele and AD.
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页码：1313 / 1316
页数：4
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