Prevalence of high-level mupirocin resistance among meticillin-resistant Staphylococcus aureus isolates in a tertiary care hospital in Singapore

被引:13
作者
Choudhury, S. [1 ]
Krishnan, P. U. [1 ]
Ang, B. [2 ]
机构
[1] Tan Tock Seng Hosp, Dept Lab Med, Singapore 308433, Singapore
[2] Tan Tock Seng Hosp, Dept Infect Dis, Singapore 308433, Singapore
关键词
Hospital; Meticillin-resistant; Staphylococcus aureus; Mupirocin; Resistance; EMERGENCE;
D O I
10.1016/j.jhin.2012.07.002
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
High-level resistance to mupirocin in meticillin-resistant Staphylococcus aureus (MRSA) jeopardizes its role in nasal decolonization protocols. We carried out a study in 2010 to determine the prevalence of high-level mupirocin resistance in our tertiary-care hospital. The prevalence of high-level resistance to mupirocin in MRSA in this hospital was 11%. There was also complete agreement between the genotypic and phenotypic methods of detection of high-level mupirocin resistance in 24 of the screening isolates. (C) 2012 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:56 / 57
页数:2
相关论文
共 8 条
[1]  
[Anonymous], 5 INT C AS PAC SOC I
[2]  
Clinical and Laboratory Standards Institute, 2010, CLSI Document M100-S20-U
[3]   The emergence of mupirocin resistance: a challenge to infection control and antibiotic prescribing practice [J].
Cookson, BD .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 41 (01) :11-18
[4]   Prevalence of clinical meticillin-resistant Staphylococcus aureus (MRSA) with high-level mupirocin resistance in Shanghai and Wenzhou, China [J].
Liu, Qing-Zhong ;
Wu, Qiong ;
Zhang, Yi-Bo ;
Liu, Mei-Na ;
Hu, Fu-Pin ;
Xu, Xiao-Gang ;
Zhu, De-Mei ;
Ni, Yu-Xing .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2010, 35 (02) :114-118
[5]   Interpretive criteria to differentiate low- and high-level mupirocin resistance in Staphylococcus aureus [J].
Moreira de Oliveira, Naira Elane ;
Couto Marques Cardozo, Ana Paula ;
de Andrade Marques, Elizabeth ;
Netto dos Santos, Katia Regina ;
Giambiagi-deMarval, Marcia .
JOURNAL OF MEDICAL MICROBIOLOGY, 2007, 56 (07) :937-939
[6]   CHARACTERIZATION OF A CONJUGATIVE STAPHYLOCOCCAL MUPIROCIN RESISTANCE PLASMID [J].
MORTON, TM ;
JOHNSTON, JL ;
PATTERSON, J ;
ARCHER, GL .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (06) :1272-1280
[7]  
Orrett FA, 2008, JPN J INFECT DIS, V61, P107
[8]   Prevalence and mechanisms of low- and high-level mupirocin resistance in staphylococci isolated from a Korean hospital [J].
Yun, HJ ;
Lee, SW ;
Yoon, GM ;
Kim, SY ;
Choi, S ;
Lee, YS ;
Choi, EC ;
Kim, S .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 51 (03) :619-623