Development of attenuated vaccines from Taiwanese infectious bronchitis virus strains

被引：45
作者：
Huang, YP [1 ]
Wang, CH [1 ]
机构：
[1] Natl Taiwan Univ, Dept Vet Med, Taipei 10617, Taiwan
来源：
VACCINE | 2006年 / 24卷 / 06期
关键词：
attenuated vaccine; infectious bronchitis virus;
D O I：
10.1016/j.vaccine.2005.08.081
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Due to variations in serotypes among different strains of avian infectious bronchitis Viruses (IBV), vaccination of chicks with imported vaccines fails to protect them front IBV infections in Taiwan. Therefore, we develop attenuated vaccines from local strains in Taiwan. A Taiwan Group I (TW I) strain was passaged 74 times through specific pathogen-free (SPF) chicken embryonated eggs, and then tested in SPF chickens. The attenuated vaccine was not pathogenic in 1-week-old chicks, had a neutralization index (NI) of greater than 4.4 and efficacy of 90% When inoculated birds were challenged with a field IBV strain. Similar results were obtained for a vaccine made from a Taiwan Group II IBV strain. Additionally, the TW I attenuated vaccine strain had no reversion to Virulence after five back passages in chicks. In conclusion, these attenuated vaccines have potential for controlling local Taiwanese IBV infections in chickens. (c) 2005 Elsevier Ltd. All rights reserved.
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收藏
页码：785 / 791
页数：7
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