Antibodies to I-125-glutamic acid decarboxylase in patients with stiff man syndrome

被引:22
作者
Vincent, A
Grimaldi, LME
Martino, G
Davenport, C
Todd, I
机构
[1] SAN RAFFAELE SCI INST, DIBIT, NEUROIMMUNOL UNIT, I-20132 MILAN, ITALY
[2] UNIV NOTTINGHAM HOSP, QUEENS MED CTR, DEPT CLIN LAB SCI, DIV MOL & CLIN IMMUNOL, NOTTINGHAM NG7 2UH, ENGLAND
关键词
stiff man syndrome; glutamic acid decarboxylase; neuromyotonia; NEUROMYOTONIA ISAACS SYNDROME; ACQUIRED NEUROMYOTONIA; DIABETES-MELLITUS; GABAERGIC NEURONS; BREAST-CANCER; AUTOANTIBODIES; PROTEIN;
D O I
10.1136/jnnp.62.4.395
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Antibodies to glutamic acid decarboxylase (GAD) are found in about 40% of patients with stiff man syndrome. A new assay involving immunoprecipitation of I-125-glutamic acid decarboxylase was used to measure anti-GAD antibodies in 18 patients with stiff man syndrome. Of the eight serum samples from patients with stiff man syndrome, that had previously been found positive by immunoprecipitation of S-35-GAD, seven were strongly positive with I-125-GAD and one gave an equivocal result. Other serum samples from patients with stiff man syndrome and from controls were negative except one from a patient who had a thymoma, acquired neuromyotonia, and myasthenia gravis. Nine of 35 serum samples referred for testing were positive; in two of these the serum titre was 20-50 times higher than that in the CSF. This assay should prove useful in the diagnosis, management, and investigation of stiff man syndrome.
引用
收藏
页码:395 / 397
页数:3
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