The shikimate pathway .8. synthesis of (-)-3(R)-amino-4(R),5(R)-dihydroxy-1-cyclohexene-1-carboxylic acid: The 3(R)-amino analogue of (-)-shikimic acid

被引：28

作者：

Adams, H

Bailey, NA

Brettle, R

Cross, R

Frederickson, M

Haslam, E

MacBeath, FS

Davies, GM

机构：

[1] UNIV SHEFFIELD,DEPT CHEM,SHEFFIELD S3 7HF,S YORKSHIRE,ENGLAND

[2] ZENECA PHARMACEUT,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

来源：

TETRAHEDRON | 1996年 / 52卷 / 25期

关键词：

D O I：

10.1016/0040-4020(96)00398-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first successful method for the introduction of nitrogenous functionality at C-3 of the shikimate nucleus has been developed and has allowed the synthesis of (-)-3(R)-amino-4(R),5(R)-dihydroxy-1-cyclohexene-1-carboxylic acid [the 3(R)-amino analogue of (-)-shikimic acid] in seven steps from the parent acid. (C) 1996 Elsevier Science Ltd

引用

页码：8565 / 8580

页数：16

共 17 条

[1] ADDITION OF AMINES TO METHYL 3-DEHYDROQUINATE AND 3-DEHYDROSHIKIMATE [J].