Discovery of Neuritogenic Compound Classes Inspired by Natural Products

被引：66
作者：
Dakas, Pierre-Yves [1 ]
Parga, Juan A. [3 ]
Hoeing, Susanne [3 ]
Schoeler, Hans R. [3 ,4 ]
Sterneckert, Jared [3 ]
Kumar, Kamal [1 ,2 ]
Waldmann, Herbert [1 ,2 ]
机构：
[1] Max Planck Inst Mol Physiol, D-44227 Dortmund, Germany
[2] Tech Univ Dortmund, Fachbereich Chem, D-44221 Dortmund, Germany
[3] Max Planck Inst Mol Biomed, Dept Cell & Dev Biol, D-48149 Munster, Germany
[4] Univ Munster, Fac Med, D-48149 Munster, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 36期
关键词：
asymmetric catalysis; iridoids; natural products; neuritogenic molecules; BAEYER-VILLIGER OXIDATION; MORITA-BAYLIS-HILLMAN; FUNCTIONALIZED CYCLOPENTENES; NEUROTROPHIC FACTORS; 3+2 ANNULATION; ALLENES; GDNF; CYCLOADDITIONS; GALANTAMINE; CATALPOL;
D O I：
10.1002/anie.201302045
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Neuroactive! An enantioselective, catalytic synthesis strategy provides rapid access to natural-product-inspired classes of neuritogenic compounds (see scheme). The goal is to find interesting chemical probes to shed light on neurodevelopmental processes and foster a better understanding of the complex biology and physiology of neuronal development and related neurodegenerative disorders. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：9576 / 9581
页数：6
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