Transporting and Shielding Photosensitisers by Using Water-Soluble Organometallic Cages: A New Strategy in Drug Delivery and Photodynamic Therapy

被引：113
作者：
Therrien, Bruno [1 ]
机构：
[1] Univ Neuchatel, Inst Chem, CH-2000 Neuchatel, Switzerland
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 26期
基金：
瑞士国家科学基金会;
关键词：
cage compounds; drug delivery; metallacages; photodynamic therapy; ruthenium; ARENE RUTHENIUM COMPLEXES; COORDINATION CAGE; CANCER; CHEMISTRY; RELEASE; RECTANGLES; PORPHYRIN; EXCHANGE; LIGANDS; HISTORY;
D O I：
10.1002/chem.201301348
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Skin photosensitivity remains one of the main limitations in photodynamic therapy. In this Concept article a strategy to overcome this limitation is described, in which the photosensitizer is hidden inside the hydrophobic cavity of a water-soluble organometallic cage. The metallacage not only protects the photosensitizer from light, it also facilitates its delivery to cancer cells.
引用
收藏
页码：8378 / 8386
页数：9
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