EspF of enteropathogenic Escherichia coli binds sorting nexin 9

被引：42

作者：

Marchés, O

Batchelor, M

Shaw, RK

Patel, A

Cummings, N

Nagai, T

Sasakawa, C

Carlsson, SR

Lundmark, R

Cougoule, C

Caron, E

Knutton, S

Connerton, I

Frankel, G

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Ctr Mol Microbiol & Infect, London SW7 2AZ, England

[3] Univ Birmingham, Inst Child Hlth, Birmingham B4 6NH, W Midlands, England

[4] Univ Nottingham, Sch Biosci, Div Food Sci, Loughborough LE12 5DR, Leics, England

[5] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Minato Ku, Tokyo 1088639, Japan

[6] Umea Univ, Dept Med Biochem & Biophys, S-90187 Umea, Sweden

来源：

JOURNAL OF BACTERIOLOGY | 2006年 / 188卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/JB.188.8.3110-3115.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

EspF of enteropathogenic Escherichia coli targets mitochondria and subverts a number of cellular functions. EspF consists of six putative Src homology 3 (SH3) domain binding motifs. In this study we identified sorting nexin 9 (SNX9) as a host cell EspF binding partner protein, which binds EspF via its amino-terminal SH3 region. Coimmunoprecipitation and confocal microscopy showed specific EspF-SNX9 interaction and nonmitochondrial protein colocalization in infected epithelial cells.

引用

收藏

页码：3110 / 3115

页数：6

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