A Machine-Assisted Flow Synthesis of SR48692: A Probe for the Investigation of Neurotensin Receptor-1

被引：60

作者：

Battilocchio, Claudio ^{[1
]}

Deadman, Benjamin J. ^{[1
]}

Nikbin, Nikzad ^{[1
]}

Kitching, Matthew O. ^{[1
]}

Baxendale, Ian R. ^{[2
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England

[2] Univ Durham, Dept Chem, Durham DH1 3LE, England

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 24期

基金：

英国工程与自然科学研究理事会;

关键词：

batch processes; flow chemistry; medicinal chemistry; organic chemistry; synthetic methods; LINE IR-ANALYSIS; PROSTATE-CANCER; CHEMISTRY; MICROREACTORS; CELL; SEPARATION; MONOLITHS; REACTORS; POTENT; GREEN;

D O I：

10.1002/chem.201300696

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we report the direct comparison of a conventional batch mode synthesis of Meclinertant (SR48692, 1), a neurotensin receptor-1 antagonist, with its machine-assisted flow chemistry alternative. By using these enabling tools, combined with solid-supported reagents and scavengers, many process advantages were observed. Care, however, must be taken not to convert these techniques into expensive solutions to problems that do not exist.

引用

页码：7917 / 7930

页数：14

共 65 条

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Adams R., 1941, ORG SYNTH, V1, P109

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