The role and influence of gut microbiota in pathogenesis and management of obesity and metabolic syndrome

被引：62

作者：

Parekh, Parth J. ^{[1
]}

Arusi, Eli ^{[1
]}

Vinik, Aaron I. ^{[2
]}

Johnson, David A. ^{[3
]}

机构：

[1] Eastern Virginia Med Sch, Dept Internal Med, Norfolk, VA 23501 USA

[2] Eastern Virginia Med Sch, Dept Internal Med, Div Endocrinol, Norfolk, VA 23501 USA

[3] Eastern Virginia Med Sch, Dept Internal Med, Div Gastroenterol, Norfolk, VA 23501 USA

来源：

FRONTIERS IN ENDOCRINOLOGY | 2014年 / 5卷

关键词：

microbiota; obesity; metabolic syndrome; insulin resistance;

D O I：

10.3389/fendo.2014.00047

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The obesity epidemic has drastically impacted the state of health care in the United States. Aside from poor diet hygiene and genetics, there are many other factors thought to play a role in the emergence of obesity and the metabolic syndrome. There has been a paradigm shift toward further investigating the gut microbiota and its implications in the pathogenesis of a variety of disease states, including inflammatory bowel disease, Clostridium difficile, and most recently obesity and the metabolic syndrome. This article is intended to evaluate the role of gut microbiota in the pathogenesis of obesity and metabolic syndrome and its influence in future management.

引用

页数：7

共 41 条

[1]

[Anonymous], 2012, BMJ CASE REP

[2] The gut microbiota as an environmental factor that regulates fat storage [J].

Bäckhed, F ;

Ding, H ;

Wang, T ;

Hooper, LV ;

Koh, GY ;

Nagy, A ;

Semenkovich, CF ;

Gordon, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) :15718-15723

[3] Mechanisms underlying the resistance to diet-induced obesity in germ-free mice [J].

Backhed, Fredrik ;

Manchester, Jill K. ;

Semenkovich, Clay F. ;

Gordon, Jeffrey I. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (03) :979-984

[4] Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet [J].

Bjursell, Mikael ;

Admyre, Therese ;

Goransson, Melker ;

Marley, Anna E. ;

Smith, David M. ;

Oscarsson, Jan ;

Bohlooly-Y, Mohammad .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2011, 300 (01) :E211-E220

[5] Fecal microbiota transplantation and emerging applications [J].

Borody, Thomas J. ;

Khoruts, Alexander .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2012, 9 (02) :88-96

[6] Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia [J].

Cani, P. D. ;

Neyrinck, A. M. ;

Fava, F. ;

Knauf, C. ;

Burcelin, R. G. ;

Tuohy, K. M. ;

Gibson, G. R. ;

Delzenne, N. M. .

DIABETOLOGIA, 2007, 50 (11) :2374-2383

[7] Metabolic endotoxemia initiates obesity and insulin resistance [J].

Cani, Patrice D. ;

Amar, Jacques ;

Iglesias, Miguel Angel ;

Poggi, Marjorie ;

Knauf, Claude ;

Bastelica, Delphine ;

Neyrinck, Audrey M. ;

Fava, Francesca ;

Tuohy, Kieran M. ;

Chabo, Chantal ;

Waget, Aurelie ;

Delmee, Evelyne ;

Cousin, Beatrice ;

Sulpice, Thierry ;

Chamontin, Bernard ;

Ferrieres, Jean ;

Tanti, Jean-Francois ;

Gibson, Glenn R. ;

Casteilla, Louis ;

Delzenne, Nathalie M. ;

Alessi, Marie Christine ;

Burcelin, Remy .

DIABETES, 2007, 56 (07) :1761-1772

[8] Outbreak of Saccharomyces cerevisiae subtype boulardii fungemia in patients neighboring those treated with a probiotic preparation of the organism [J].

Cassone, M ;

Serra, P ;

Mondello, F ;

Girolamo, A ;

Scafetti, S ;

Pistella, E ;

Venditti, M .

JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (11) :5340-5343

[9] Saccharomyces cerevisiae boulardii transient fungemia after intravenous self-inoculation [J].

Cohen, Lola ;

Ranque, Stephane ;

Raoult, Didier .

MEDICAL MYCOLOGY CASE REPORTS, 2013, 2 :63-64

[10] Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease? [J].

Conterno, Lorenza ;

Fava, Francesca ;

Viola, Roberto ;

Tuohy, Kieran M. .

GENES AND NUTRITION, 2011, 6 (03) :241-260

← 1 2 3 4 5 →