Blood Beta-Amyloid and Tau in Down Syndrome: A Comparison with Alzheimer's Disease

被引:36
作者
Lee, Ni-Chung [1 ,2 ]
Yang, Shieh-Yueh [3 ]
Chieh, Jen-Jie [4 ]
Huang, Po-Tsang [5 ]
Chang, Lih-Maan [5 ]
Chiu, Yen-Nan [6 ]
Huang, Ai-Chiu [2 ]
Chien, Yin-Hsiu [1 ,2 ]
Hwu, Wuh-Liang [1 ,2 ]
Chiu, Ming-Jang [7 ,8 ,9 ,10 ]
机构
[1] Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Pediat, Taipei, Taiwan
[2] Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Med Genet, Taipei, Taiwan
[3] MagQu Co Ltd, New Taipei, Taiwan
[4] Natl Taiwan Normal Univ, Inst Electroopt Sci & Technol, Taipei, Taiwan
[5] Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Clin Psychol Ctr, Taipei, Taiwan
[6] Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Psychiat, Taipei, Taiwan
[7] Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Neurol, Taipei, Taiwan
[8] Natl Taiwan Univ, Coll Med, Grad Inst Brain & Mind Sci, Taipei, Taiwan
[9] Natl Taiwan Univ, Dept Psychol, Taipei, Taiwan
[10] Natl Taiwan Univ, Grad Inst Biomed Engn & Bioinformat, Taipei, Taiwan
来源
FRONTIERS IN AGING NEUROSCIENCE | 2017年 / 8卷
关键词
beta-amyloids; Down syndrome; behavioral and psychological symptoms of dementia; Alzheimer's disease; dementia; tau protein; MILD COGNITIVE IMPAIRMENT; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; MEMORY FUNCTION; DEMENTIA; ADULTS; RECOMMENDATIONS; BIOMARKERS; ONSET;
D O I
10.3389/fnagi.2016.00316
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background: Changes in beta-amyloids (A beta) and tau proteins have been noted in patients with Alzheimers disease (AD) and patients with both Down syndrome (DS) and AD. However, reports of changes in the early stage of regression, such as behavioral and psychological symptoms of dementia (BPSD), in DS are sparse. Methods: Seventy-eight controls, 62 patients with AD, 35 with DS and 16 with DS with degeneration (DS_D), including 9 with BPSD and 7 with dementia, were enrolled. The levels of beta-amyloids 40 and 42 (A beta-40, A beta-42) and tau protein in the blood were analyzed using immunomagnetic reduction (IMR). The Adaptive Behavior Dementia Questionnaire (ABDQ) was used to evaluate the clinical status of the degeneration. Results: The A beta-40 and tau levels were higher and the A beta-42 level and A beta-42/A beta-40 ratio were lower in DS than in the controls (all p < 0.001). Decreased A beta-40 and increased A beta-42 levels and A beta-42/40 ratios were observed in DS_D compared with DS without degeneration (all p < 0.001). The ABDQ score was negatively correlated with the A beta-40 level (rho = -0.556) and the tau protein level (rho = -0.410) and positively associated with the A beta-42 level (rho = 0.621) and the A beta-42/40 ratio (rho = 0.544; all p < 0.05). Conclusions: The A beta-40 and A beta-42 levels and the A beta-42/A beta-40 ratio are considered possible biomarkers for the early detection of degeneration in DS. The elevated A beta-40 and tau levels in DS may indicate early neurodegeneration. The increased A beta-42 in DS_D may reflect the neurotoxicity of A beta-42. The paradox of the tau decreases in DS_D could be explained by a burnout phenomenon during long-term neurodegeneration. The different patterns of the plasma beta amyloids and tau protein may imply a different pathogenesis between DS with degeneration and AD in the general population, in spite of their common key pathological features.
引用
收藏
页数:8
相关论文
共 50 条
[21]   Cerebrospinal Tau, Phospho-Tau, and Beta-Amyloid and Neuropsychological Functions in Parkinson's Disease [J].
Compta, Yaroslau ;
Marti, Maria J. ;
Ibarretxe-Bilbao, Naroa ;
Junque, Carme ;
Valldeoriola, Francesc ;
Munoz, Esteban ;
Ezquerra, Mario ;
Rios, Jose ;
Tolosa, Eduardo .
MOVEMENT DISORDERS, 2009, 24 (15) :2203-2210
[22]   Beta-Amyloid Peptide in Tears: An Early Diagnostic Marker of Alzheimer's Disease Correlated with Choroidal Thickness [J].
Gharbiya, Magda ;
Visioli, Giacomo ;
Trebbastoni, Alessandro ;
Albanese, Giuseppe Maria ;
Colardo, Mayra ;
D'Antonio, Fabrizia ;
Segatto, Marco ;
Lambiase, Alessandro .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (03)
[23]   Structural Connectivity Alterations Along the Alzheimer's Disease Continuum: Reproducibility Across Two Independent Samples and Correlation with Cerebrospinal Fluid Amyloid-β and Tau [J].
Tucholka, Alan ;
Grau-Rivera, Oriol ;
Falcon, Carles ;
Rami, Lorena ;
Sanchez-Valle, Raquel ;
Llado, Albert ;
Domingo Gispert, Juan ;
Luis Molinuevo, Jose .
JOURNAL OF ALZHEIMERS DISEASE, 2018, 61 (04) :1575-1587
[24]   Further understanding the connection between Alzheimer's disease and Down syndrome [J].
Snyder, Heather M. ;
Bain, Lisa J. ;
Brickman, Adam M. ;
Carrillo, Maria C. ;
Esbensen, Anna J. ;
Espinosa, Joaquin M. ;
Fernandez, Fabian ;
Fortea, Juan ;
Hartley, Sigan L. ;
Head, Elizabeth ;
Hendrix, James ;
Kishnani, Priya S. ;
Lai, Florence ;
Lao, Patrick ;
Lemere, Cynthia ;
Mobley, William ;
Mufson, Elliott J. ;
Potter, Huntington ;
Zaman, Shahid H. ;
Granholm, Ann-Charlotte ;
Rosas, H. Diana ;
Strydom, Andre ;
Whitten, Michelle Sie ;
Rafii, Michael S. .
ALZHEIMERS & DEMENTIA, 2020, 16 (07) :1065-1077
[25]   Temporal trajectories of in vivo tau and amyloid-β accumulation in Alzheimer's disease [J].
Baek, Min Seok ;
Cho, Hanna ;
Lee, Hye Sun ;
Choi, Jae Yong ;
Lee, Jae Hoon ;
Ryu, Young Hoon ;
Lee, Myung Sik ;
Lyoo, Chul Hyoung .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2020, 47 (12) :2879-2886
[26]   Tau, amyloid, and cascading network failure across the Alzheimer's disease spectrum [J].
Jones, David T. ;
Graff-Radford, Jonathan ;
Lowe, Val J. ;
Wiste, Heather J. ;
Gunter, Jeffrey L. ;
Senjem, Matthew L. ;
Botha, Hugo ;
Kantarci, Kejal ;
Boeve, Bradley F. ;
Knopman, David S. ;
Petersen, Ronald C. ;
Jack, Clifford R., Jr. .
CORTEX, 2017, 97 :143-159
[27]   Evaluation of Cerebrospinal Fluid Tau/Beta-Amyloid(42) Ratio as Diagnostic Markers for Alzheimer Disease [J].
Smach, Mohamed Ali ;
Charfeddine, Bassem ;
Othman, Leila Ben ;
Lammouchi, Turkia ;
Dridi, Hedi ;
Nafati, Souhir ;
Ltaief, Afef ;
Bennamou, Soufien ;
Limem, Khalifa .
EUROPEAN NEUROLOGY, 2009, 62 (06) :349-355
[28]   Beta-amyloid and Cortical Thickness Reveal Racial Disparities in Preclinical Alzheimer's Disease [J].
McDonough, Ian M. .
NEUROIMAGE-CLINICAL, 2017, 16 :659-667
[29]   Complement dysregulation and Alzheimer's disease in Down syndrome [J].
Veteleanu, Aurora ;
Pape, Sarah ;
Davies, Kate ;
Kodosaki, Eleftheria ;
Hye, Abdul ;
Zelek, Wioleta M. ;
Strydom, Andre ;
Morgan, B. Paul .
ALZHEIMERS & DEMENTIA, 2023, 19 (04) :1383-1392
[30]   Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer's Disease: Systematic Review and Meta-Analysis [J].
Zabala-Findlay, Alex ;
Penny, Lewis K. ;
Lofthouse, Richard A. ;
Porter, Andrew J. ;
Palliyil, Soumya ;
Harrington, Charles R. ;
Wischik, Claude M. ;
Arastoo, Mohammad .
CELLS, 2023, 12 (08)