Chemical constituents of hemp (Cannabis sativa L.) seed with potential anti-neuroinflammatory activity

被引：59
|
作者：
Zhou, Yuefang [1 ]
Wang, Shanshan [1 ]
Lou, Hongxiang [1 ]
Fan, Peihong [1 ]
机构：
[1] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol,Dept Nat Prod Chem, Jinan 250012, Shandong, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2018年 / 23卷
基金：
中国国家自然科学基金;
关键词：
Hemp seed; Cannabis sativa L; Lignanamides; Glycoside; Anti-neuroinflammatory activity; NF-KAPPA-B; BV2 MICROGLIA CELLS; IDENTIFICATION; FRUITS; LIGNANAMIDES; AMIDES;
D O I：
10.1016/j.phytol.2017.11.013
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new lignanamide (1) and a new coumaroylamino glycoside derivative (2) were isolated and identified from hemp (Cannabis sativa L.) seed along with eighteen known compounds (3-20), eight (9, 10, 14-18, 20) of which were isolated for the first time from hemp seed. Their anti-neuroinflammatory activity on LPS (lipopolysaccharide)-induced BV2 microglia cells was evaluated. Compounds 1, 2, 5-9, 12, 13, 15-17, 19 and 20 exhibited significant inhibitory effects on TNF-alpha release from LPS-induced BV2 microglia cells, especially the new glucoside 2. The results laid a solid foundation for additional research on hemp seed related to its value against neurodegenerative diseases.
引用
收藏
页码：57 / 61
页数：5
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