DNA methylation: roles in mammalian development

被引：2230
作者：
Smith, Zachary D.
Meissner, Alexander [1 ]
机构：
[1] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA
来源：
NATURE REVIEWS GENETICS | 2013年 / 14卷 / 03期
基金：
美国国家卫生研究院;
关键词：
EMBRYONIC STEM-CELLS; DE-NOVO METHYLATION; LYSINE METHYLTRANSFERASE G9A; MAJOR SATELLITE REPEATS; CPG ISLAND METHYLATION; PRIMORDIAL GERM-CELLS; HEMATOPOIETIC STEM; SELF-RENEWAL; HISTONE DEACETYLASE; PATERNAL GENOME;
D O I：
10.1038/nrg3354
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
DNA methylation is among the best studied epigenetic modifications and is essential to mammalian development. Although the methylation status of most CpG dinucteotides in the genome is stably propagated through mitosis, improvements to methods for measuring methylation have identified numerous regions in which it is dynamically regulated. In this Review, we discuss key concepts in the function of DNA methylation in mammals, stemming from more than two decades of research, including many recent studies that have elucidated when and where DNA methylation has a regulatory role in the genome. We include insights from early development, embryonic stem cells and adult Lineages, particularly haematopoiesis, to highlight the general features of this modification as it participates in both global and localized epigenetic regulation..
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页码：204 / 220
页数：17
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