Determinants of nucleosome positioning

被引：494

作者：

Struhl, Kevin ^{[1
]}

Segal, Eran ^{[2
,3
]}

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[2] Weizmann Inst Sci, Dept Comp Sci & Appl Math, IL-76100 Rehovot, Israel

[3] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2013年 / 20卷 / 03期

基金：

美国国家卫生研究院; 欧洲研究理事会;

关键词：

HISTONE-DNA INTERACTIONS; GENE-EXPRESSION; HIGH-RESOLUTION; IN-VITRO; CHROMATIN; YEAST; TRANSCRIPTION; ORGANIZATION; REVEALS; SEQUENCES;

D O I：

10.1038/nsmb.2506

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nucleosome positioning is critical for gene expression and most DNA-related processes. Here we review the dominant patterns of nucleosome positioning that have been observed and summarize the current understanding of their underlying determinants. The genome-wide pattern of nucleosome positioning is determined by the combination of DNA sequence, ATP-dependent nucleosome remodeling enzymes and transcription factors that include activators, components of the preinitiation complex and elongating RNA polymerase II. These determinants influence each other such that the resulting nucleosome positioning patterns are likely to differ among genes and among cells in a population, with consequent effects on gene expression.

引用

页码：267 / 273

页数：7

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