Synthesis and biological activities of novel dialkyl (4-trifluoromethylphenylamino)-(4-trifluoromethyl or 3-fluorophenyl) methylphosphonates

被引：26

作者：

Zhang, GP ^{[1
]}

Song, B ^{[1
]}

Xue, W ^{[1
]}

Jin, LH ^{[1
]}

Hu, DY ^{[1
]}

Wan, QQ ^{[1
]}

Lu, P ^{[1
]}

Wang, H ^{[1
]}

Yang, S ^{[1
]}

Li, QZ ^{[1
]}

Liu, G ^{[1
]}

机构：

[1] Guizhou Univ, Minist Educ Res & Dev, Ctr Fine Chem, Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Peoples R China

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2006年 / 127卷 / 01期

基金：

中国国家自然科学基金;

关键词：

aminoalkylphosphonates; 4-trifluoromethylphenyl; 3-fluorophenyl; synthesis; anticancer activity; anti-TMV activity; microwave irradiation;

D O I：

10.1016/j.jfluchem.2005.09.014

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of novel dialkyl (4-trifluoromethylphenylamino)-(4-trifluoromethyl or 3-fluorophenyl) methylphosphonates 3 were synthesized through the reaction of 3-fluorobenzaldehyde or 4-trifluoromethylbenzaldehyde and 4-trifluoromethylaniline with dialkyl phosphite by microwave irradiation using boron trifluoride-ether catalyst and their structures were clearly verified by spectroscopic data (IR, H-1 NMR and elemental analysis). The results of bioassay showed that these title compounds possess potential anticancer activities in vitro by MTT method. At the same time, we found these title compounds exhibit moderate antiviral activity against tobacco mosaic virus. (C) 2005 Elsevier B.V. All rights reserved.

引用

页码：48 / 53

页数：6

共 29 条

[11] Structure-activity relationships for pyrido-, imidazo-, pyrazolo-, pyrazino-, and pyrrolophenazinecarboxamides as topoisomerase-targeted anticancer agents [J].