Near-infrared photocontrolled therapeutic release via upconversion nanocomposites

被引:29
作者
Wang, Zhimin [1 ]
Thang, Do Cong [1 ]
Han, Qingyu [1 ]
Zhao, Xuan [2 ]
Xie, Xilei [3 ]
Wang, Zhiyong [4 ]
Lin, Jun [5 ]
Xing, Bengang [1 ]
机构
[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore
[2] Fuzhou Univ, Coll Chem, Natl & Local Joint Biomed Engn Res Ctr Photodynam, Fuzhou 350116, Fujian, Peoples R China
[3] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Mol & Nano Probes,Minist Educ, Minist Educ,Collaborat Innovat Ctr Functionalized, Jinan 250014, Peoples R China
[4] Sun Yat Sen Univ, Sch Mat Sci & Engn, Guangzhou 510275, Peoples R China
[5] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China
基金
中国国家自然科学基金;
关键词
Near-infrared light; Photocontrolled release; Upconversion nanocomposites; Therapeutics; Bioimaging; VIVO PHOTODYNAMIC THERAPY; IN-VIVO; DRUG-DELIVERY; TARGETED THERAPIES; UPCONVERTING NANOPARTICLES; CANCER-THERAPY; NITRIC-OXIDE; THERANOSTIC PLATFORM; LIGHT; SHELL;
D O I
10.1016/j.jconrel.2020.05.011
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Photocontrolled therapeutic release holds great promise due to its versatile manipulability, superb spatiotemporal precision and minimal tissue invasiveness in biomedical purposes. However, most of light-responsive platforms thus far have relied on UV or visible light which substantially limit the potential applicability in living animals. In recent decades, near-infrared (NIR) light-mediated theranostic upconversion nanocomposites (UCNCs) that integrate conventional UV/Vis-sensitive materials and classic lanthanide-doped upconversion nanoparticles (UCNPs) have significantly promoted the development of deep-tissue photoreleasable therapeutics in vivo. Herein, we seek to review current NIR upconversion triggered photorelease techniques and their diverse applications in the biological regulation, as well as diseases therapy. In addition, the future perspectives and challenges for advancing UCNCs based NIR photoreleasable nanotherapeutics into clinical translations are proposed.
引用
收藏
页码:104 / 123
页数:20
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