Role of MicroRNAs in Lung Disease

被引：95
作者：
Angulo, Martin [1 ,2 ]
Lecuona, Emilia [1 ]
Iasha Sznajder, Jacob [1 ]
机构：
[1] Northwestern Univ, Feinberg Sch Med, Div Pulm & Crit Care, Chicago, IL 60611 USA
[2] Univ Republica, Fac Med, Hosp Clin, Dept Fisiopatol, Montevideo, Uruguay
来源：
ARCHIVOS DE BRONCONEUMOLOGIA | 2012年 / 48卷 / 09期
关键词：
MicroRNA; Lung disease; Smoking; Chronic obstructive pulmonary disease; Lung cancer; Pulmonary fibrosis; Lung injury; Asthma; OBSTRUCTIVE PULMONARY-DISEASE; DOWN-REGULATION; REDUCED EXPRESSION; CANCER; SURVIVAL; TARGET; MUSCLE; SPUTUM; CELLS; IDENTIFICATION;
D O I：
10.1016/j.arbres.2012.04.011
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
MicroRNAs (miRNAs) are small non-coding RNA molecules that negatively regulate gene expression. They actively participate in the modulation of important cell physiological processes and are involved in the pathogenesis of lung diseases such as lung cancer, pulmonary fibrosis, asthma and chronic obstructive pulmonary disease. A better understanding of the role that miRNAs play in these diseases could lead to the development of new diagnostic and therapeutic tools. In this review, we discuss the role of some miRNAs in different lung diseases as well as the possible future of these discoveries in clinical applications. (C) 2012 SEPAR. Published by Elsevier Espana, S.L. All rights reserved.
引用
收藏
页码：325 / 330
页数：6
相关论文
共 76 条
[21]  
Jemal A, 2009, CA-CANCER J CLIN, V59, P225, DOI [10.3322/caac.20006, 10.3322/caac.21387]
[22]   In Vivo Identification of Tumor-Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma [J].
Karreth, Florian A. ;
Tay, Yvonne ;
Perna, Daniele ;
Ala, Ugo ;
Tan, Shen Mynn ;
Rust, Alistair G. ;
DeNicola, Gina ;
Webster, Kaitlyn A. ;
Weiss, Dror ;
Perez-Mancera, Pedro A. ;
Krauthammer, Michael ;
Halaban, Ruth ;
Provero, Paolo ;
Adams, David J. ;
Tuveson, David A. ;
Pandolfi, Pier Paolo .
CELL, 2011, 147 (02) :382-395
[23]   Reduced expression of Dicer associated with poor prognosis in lung cancer patients [J].
Karube, Y ;
Tanaka, H ;
Osada, H ;
Tomida, S ;
Tatematsu, Y ;
Yanagisawa, K ;
Yatabe, Y ;
Takamizawa, J ;
Miyoshi, S ;
Mitsudomi, T ;
Takahashi, T .
CANCER SCIENCE, 2005, 96 (02) :111-115
[24]   Idiopathic pulmonary fibrosis [J].
King, Talmadge E., Jr. ;
Pardo, Annie ;
Selman, Moises .
LANCET, 2011, 378 (9807) :1949-1961
[25]   Chronic Obstructive Pulmonary Disease and Altered Risk of Lung Cancer in a Population-Based Case-Control Study [J].
Koshiol, Jill ;
Rotunno, Melissa ;
Consonni, Dario ;
Pesatori, Angela Cecilia ;
De Matteis, Sara ;
Goldstein, Alisa M. ;
Chaturvedi, Anil K. ;
Wacholder, Sholom ;
Landi, Maria Teresa ;
Lubin, Jay H. ;
Caporaso, Neil E. .
PLOS ONE, 2009, 4 (10)
[26]   miRBase: integrating microRNA annotation and deep-sequencing data [J].
Kozomara, Ana ;
Griffiths-Jones, Sam .
NUCLEIC ACIDS RESEARCH, 2011, 39 :D152-D157
[27]   The widespread regulation of microRNA biogenesis, function and decay [J].
Krol, Jacek ;
Loedige, Inga ;
Filipowicz, Witold .
NATURE REVIEWS GENETICS, 2010, 11 (09) :597-610
[28]   THE C-ELEGANS HETEROCHRONIC GENE LIN-4 ENCODES SMALL RNAS WITH ANTISENSE COMPLEMENTARITY TO LIN-14 [J].
LEE, RC ;
FEINBAUM, RL ;
AMBROS, V .
CELL, 1993, 75 (05) :843-854
[29]   Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD [J].
Lewis, Amy ;
Riddoch-Contreras, Joanna ;
Natanek, Samantha A. ;
Donaldson, Anna ;
Man, William D-C ;
Moxham, John ;
Hopkinson, Nicholas S. ;
Polkey, Michael I. ;
Kemp, Paul R. .
THORAX, 2012, 67 (01) :26-34
[30]   MicroRNA in lung cancer [J].
Lin, P-Y ;
Yu, S-L ;
Yang, P-C .
BRITISH JOURNAL OF CANCER, 2010, 103 (08) :1144-1148
12345678