Gelatin-Based Emulsion Hydrogels as a Matrix for Controlled Delivery System

被引：16

作者：

Mallick, Sarada ^{[1
]}

Sagiri, Sai Sateesh ^{[1
]}

Behera, Beauty ^{[1
]}

Pal, Kunal ^{[1
]}

Ray, Sirsendu S. ^{[1
]}

机构：

[1] Natl Inst Technol, Dept Biotechnol & Med Engn, Rourkela 769008, India

来源：

MATERIALS AND MANUFACTURING PROCESSES | 2012年 / 27卷 / 11期

关键词：

Adhesion; Biomaterials; Characterization; Impedance; Microscopy; Microstructure; Polymer; Spectroscopy; DRUG-DELIVERY; CROSS-LINKING; OIL DROPLETS; VISCOELASTIC PROPERTIES; CELLULOSE ACRYLATE; LIPOPHILIC DRUGS; O/W EMULSION; RELEASE; GELS; MICROSPHERES;

D O I：

10.1080/10426914.2012.663133

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The study describes the development of gelatin based emulsion hydrogels with different proportions of sunflower oil. During the preparation of emulsion hydrogels, the microstructures of the emulsions were studied under light microscope. The hydrogels were characterized by light microscopy, swelling property, mucoadhesivity, pH, dc impedance measurements, and hemocompatibility studies. Salicylic acid was incorporated within the oil phase, and its release behavior was studied. The microscopy of the emulsions indicated that the droplet size distribution becomes monodispersed as the proportion of the oil was increased. The microscopy of the emulsion hydrogels showed distorted oil droplets for all the samples. The swelling property, mucoadhesivity, dc impedance measurements, and release rate of salicylic acid were found to dependent on the oil proportion. All the samples were found to have pH in the range of 6.00-7.00 and were hemocompatible in nature, indicating its probable use as controlled delivery vehicles.

引用

页码：1221 / 1228

页数：8

共 45 条

[1] Novel mechanisms and devices to enable successful transdermal drug delivery [J].

Barry, BW .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2001, 14 (02) :101-114

[2] Stabilization of gelatin films by crosslinking with genipin [J].

Bigi, A ;

Cojazzi, G ;

Panzavolta, S ;

Roveri, N ;

Rubini, K .

BIOMATERIALS, 2002, 23 (24) :4827-4832

[3] Mechanical and thermal properties of gelatin films at different degrees of glutaraldehyde crosslinking [J].

Bigi, A ;

Cojazzi, G ;

Panzavolta, S ;

Rubini, K ;

Roveri, N .

BIOMATERIALS, 2001, 22 (08) :763-768

[4] Pectin-based microspheres for colon-specific delivery of vancomycin [J].

Bigucci, Federica ;

Luppi, Barbara ;

Monaco, Libera ;

Cerchiara, Teresa ;

Zecchi, Vittorio .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2009, 61 (01) :41-46

[5] PARTITION-COEFFICIENT AND BIOACCUMULATION OF SELECTED ORGANIC CHEMICALS [J].

CHIOU, CT ;

FREED, VH ;

SCHMEDDING, DW ;

KOHNERT, RL .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1977, 11 (05) :475-478

[6]

Dhakar R.C., 2010, hit. J. Pharma. Res. Den, V2, P56

[7] Rheology of milk protein gels and protein-stabilized emulsion gels cross-linked with transglutaminase [J].

Dickinson, E ;

Yamamoto, Y .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1996, 44 (06) :1371-1377

[8] Viscoelastic properties of heat-set whey protein-stabilized emulsion gels with added lecithin [J].

Dickinson, E ;

Yamamoto, Y .

JOURNAL OF FOOD SCIENCE, 1996, 61 (04) :811-816

[9] Organogel-Based Emulsion Systems, Micro-Structural Features and Impact on In Vitro Digestion [J].

Duffy, Nicola ;

Blonk, Han C. G. ;

Beindorff, Christiaan M. ;

Cazade, Magali ;

Bot, Arjen ;

Duchateau, Guus S. M. J. E. .

JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 2009, 86 (08) :733-741

[10] GELATIN-ACACIA MICROCAPSULES FOR TRAPPING MICRO OIL DROPLETS CONTAINING LIPOPHILIC DRUGS AND READY DISINTEGRATION IN THE GASTROINTESTINAL-TRACT [J].

JIZOMOTO, H ;

KANAOKA, E ;

SUGITA, K ;

HIRANO, K .

PHARMACEUTICAL RESEARCH, 1993, 10 (08) :1115-1122

← 1 2 3 4 5 →