5-fluoro-1-(3,4-dideoxy-3-fluoro-6-0-trityl-beta-D- glycero-hex-3-eno-pyranos-2-ulosyl (uracil): Anticancer agent

被引：6

作者：

Ollapally, AP ^{[1
]}

Bennouna-Dorange, I ^{[1
]}

Whitaker, TL ^{[1
]}

机构：

[1] Florida A&M Univ, Dept Chem, Tallahassee, FL 32307 USA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 4-5期

关键词：

D O I：

10.1080/15257779908041547

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1,2:5,6-Di-O-isopropylidene glucofuranose on mild oxidation, reduction, fluorination and deisopropylidenation followed by acetylation gave peracetylated 3-deoxy-3-fluoro-alpha-D-glucopyranose. This was coupled with silylated 5 fluorouracil. The nucleoside was deacetylated and after several subsequent protection and deprotection and final oxidation afforded the title compound.

引用

页码：703 / 705

页数：3

共 4 条

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