Efficient microwave assisted synthesis of optically active bicyclic 2-pyridinones via Δ2-thiazolines

被引：38

作者：

Emtenas, Hans ^{[1
]}

Taflin, Camilla ^{[1
]}

Almqvist, Fredrik ^{[1
]}

机构：

[1] Umea Univ, Dept Chem, SE-90187 Umea, Sweden

来源：

MOLECULAR DIVERSITY | 2003年 / 7卷 / 2-4期

关键词：

cycloaddition; Meldrum's acid; microwave; pyridone; thiazoline; 2-pyridinone;

D O I：

10.1023/B:MODI.0000006800.46154.99

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new efficient synthesis of optically active bicyclic 2-pyridiones has been developed using microwave irradiation. The synthesis is a two-step procedure via Delta(2)-thiazolines, which only requires a 3 + 2 min reaction time compared to 2 days when using conventional heating. The optimized conditions proved to be suitable for the synthesis of a small library in excellent yields and with limited racemizations.

引用

页码：165 / 169

页数：5

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