Repeatable Vaporization of Optically Vaporizable Perfluorocarbon Droplets for Photoacoustic Contrast Enhanced Imaging

被引:21
作者
Asami, Rei [1 ]
Kawabata, Kenichi [1 ]
机构
[1] Hitachi Ltd, Cent Res Lab, Tokyo, Japan
来源
2012 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS) | 2012年
关键词
contrast agent; droplets; photoacoustic imaging; perfluorocarbon;
D O I
10.1109/ULTSYM.2012.0299
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Perflurorocarbon droplets that can be vaporized optically over multiple laser pulse applications are formulated. Photoacoustic contrast agents (PC As) are important in visualizing molecular targets, deeply seated lesions, and vasculature. A novel PCA consisting of optically vaporizable perfluorocarbon droplets (OPDs) was investigated in this study. It has been reported that OPDs vaporize and emit a unique acoustic signal stronger than that from a light absorber alone, but that it only happened once at the time of vaporization. Our goal is to obtain repeatable vaporization of OPDs in order to sustain a high photoacoustic signal caused by vaporization over multiple laser pulse applications. By changing the contents of droplets to a compound with a higher boiling point, repeatable vaporization was successfully accomplished. Three times higher photoacoustic signals were produced repeatedly by droplets that exhibit transient vaporization behavior, namely PFH droplets within the size range of 0.2 - 1 mu m.
引用
收藏
页码:1200 / 1203
页数:4
相关论文
共 9 条
[1]   Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging [J].
Agarwal, A. ;
Huang, S. W. ;
O'Donnell, M. ;
Day, K. C. ;
Day, M. ;
Kotov, N. ;
Ashkenazi, S. .
JOURNAL OF APPLIED PHYSICS, 2007, 102 (06)
[2]   Quantitative Photoacoustic Image Reconstruction using Fluence Dependent Chromophores [J].
Cox, B. T. ;
Laufer, J. G. ;
Beard, P. C. .
BIOMEDICAL OPTICS EXPRESS, 2010, 1 (01) :201-208
[3]   Nanoparticles with multiple perfluorocarbons for controllable ultrasonically induced phase shifting [J].
Kawabata, K ;
Sugita, N ;
Yoshikawa, H ;
Azuma, T ;
Umemura, S .
JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS, 2005, 44 (6B) :4548-4552
[4]   Sustaining Microbubbles Derived from Phase Change Nanodroplet by Low-Amplitude Ultrasound Exposure [J].
Kawabata, Ken-ichi ;
Asami, Rei ;
Yoshikawa, Hideki ;
Azuma, Takashi ;
Umemura, Shin-ichiro .
JAPANESE JOURNAL OF APPLIED PHYSICS, 2010, 49 (07)
[5]   Acoustic droplet vaporization for therapeutic and diagnostic applications [J].
Kripfgans, OD ;
Fowlkes, JB ;
Miller, DL ;
Eldevik, OP ;
Carson, PL .
ULTRASOUND IN MEDICINE AND BIOLOGY, 2000, 26 (07) :1177-1189
[6]   Noninvasive in vivo spectroscopic nanorod-contrast photoacoustic mapping of sentinel lymph nodes [J].
Song, Kwang Hyun ;
Kim, Chulhong ;
Maslov, Konstantin ;
Wang, Lihong V. .
EUROPEAN JOURNAL OF RADIOLOGY, 2009, 70 (02) :227-231
[7]   Vaporization of perfluorocarbon droplets using optical irradiation [J].
Strohm, Eric ;
Rui, Min ;
Gorelikov, Ivan ;
Matsuura, Naomi ;
Kolios, Michael .
BIOMEDICAL OPTICS EXPRESS, 2011, 2 (06) :1432-1442
[8]   Photoacoustic imaging in biomedicine [J].
Xu, MH ;
Wang, LHV .
REVIEW OF SCIENTIFIC INSTRUMENTS, 2006, 77 (04)
[9]   Photoacoustic tomography of a rat cerebral cortex in vivo with au nanocages as an optical contrast agent [J].
Yang, Xinmai ;
Skrabalak, Sara E. ;
Li, Zhi-Yuan ;
Xia, Younan ;
Wang, Lihong V. .
NANO LETTERS, 2007, 7 (12) :3798-3802