Nine Cases of Omeprazole Allergy: Cross-Reactivity Between Proton Pump Inhibitors

被引:0
作者
Lobera, T. [1 ]
Navarro, B. [1 ]
Del Pozo, M. D. [1 ]
Gonzalez, I. [1 ]
Blasco, A. [1 ]
Escudero, R. [1 ]
Venturini, M. [1 ]
Alarcon, E. [1 ]
机构
[1] Hosp San Pedro San Millan, Dept Allergy, Logrono, Spain
关键词
Proton pump inhibitors; Omeprazole; Lansoprazole; Drug allergy; Cross-reactivity; ANAPHYLAXIS; PANTOPRAZOLE; DIAGNOSIS; LANSOPRAZOLE; ANGIOEDEMA; SHOCK;
D O I
暂无
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Although rare, anaphylactic reactions induced by proton pump inhibitors have been reported. The presence of cross-reactivity between different members of the group is not clear. We studied 9 patients with adverse reactions to omeprazole, Clinical symptoms appeared immediately in 8 patients and after 4 hours in 1. Symptoms ranged from urticaria/angioedema in 7 cases to anaphylaxis in 2 cases. Skin prick tests and oral controlled challenge tests with omeprazole, lansoprazole, and pantoprazole were performed. Skin prick or intradermal tests with omeprazole were positive in 8 patients. Four were also positive to pantoprazole. Prick tests with lansoprazole were always negative. Lansoprazole was administered to all 9 patients, with good tolerance in 8. Only 3 patients were challenged with pantoprazole and developed widespread urticaria. We present 9 patients with immunoglobulin E-mediated allergy to omeprazole. In most of our cases, lansoprazole proved to be a good alternative treatment.
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页码:57 / 60
页数:4
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