Amyloid beta 25-35 impairs reconsolidation of object recognition memory in rats and this effect is prevented by lithium carbonate

被引：10
作者：
Alvarez-Ruiz, Yarummy [1 ]
Carrillo-Mora, Paul [2 ]
机构：
[1] Univ Nacl Autonoma Mexico, Mexico City 04510, DF, Mexico
[2] Inst Natl Rehabil, Dept Neurorrehabil, Mexico City 14389, DF, Mexico
来源：
NEUROSCIENCE LETTERS | 2013年 / 548卷
关键词：
Memory reconsolidation; Amyloid beta; Lithium carbonate; Object recognition memory; Alzheimer's disease; ALZHEIMERS-DISEASE; SYNAPTIC PLASTICITY; RECEPTORS; PEPTIDE; UPDATE; OLIGOMERS; AMYGDALA; BRAIN; MODEL;
D O I：
10.1016/j.neulet.2013.06.003
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Previous studies in transgenic mice models of Alzheimer's disease (AD) have demonstrated an age dependent memory reconsolidation failure, suggesting that this may be an additional mechanism that contributes to the memory impairment observed in AD. However, so far it is unknown whether this effect can be caused by exogenous administration of amyloid beta (A beta). The purpose was to determine the effects of soluble A beta 25-35 on reconsolidation of object recognition memory (ORM) in rats, and assess whether these effects can be prevented by lithium carbonate (LiCa). In this study, male Wistar rats were used and the following groups were formed (N=6-13): (a) control, given saline solution; (b) [NMDA antagonist] MK-801 (0.1 mg/kg); (c) LiCa (350 mg/kg); (d) A beta 25-35 (100 mu M) injected into both hippocampi; and (e) A beta 25-35 + LiCa. In all cases, treatments were administered with or without reactivation of memory. The results showed that soluble A beta 25-35 produces ORM impairment similar to MK-801 when given shortly after memory reactivation, and this effect is prevented by prior administration of LiCa. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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页码：79 / 83
页数：5
相关论文
共 40 条
[11]   A NEW ONE-TRIAL TEST FOR NEUROBIOLOGICAL STUDIES OF MEMORY IN RATS .1. BEHAVIORAL-DATA [J].
ENNACEUR, A ;
DELACOUR, J .
BEHAVIOURAL BRAIN RESEARCH, 1988, 31 (01) :47-59
[12]   Aβ oligomers inhibit synapse remodelling necessary for memory consolidation [J].
Freir, Darragh B. ;
Fedriani, Rocio ;
Scully, Darren ;
Smith, Imelda M. ;
Selkoe, Dennis J. ;
Walsh, Dominic M. ;
Regan, Ciaran M. .
NEUROBIOLOGY OF AGING, 2011, 32 (12) :2211-2218
[13]   Lithium: Updated Human Knowledge Using an Evidence-Based Approach Part II: Clinical Pharmacology and Therapeutic Monitoring [J].
Grandjean, Etienne Marc ;
Aubry, Jean-Michel .
CNS DRUGS, 2009, 23 (04) :331-349
[14]   Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide [J].
Haass, Christian ;
Selkoe, Dennis J. .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (02) :101-112
[15]   Soluble beta-amyloid[25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning [J].
Holscher, Christian ;
Gengler, Simon ;
Gault, Victor A. ;
Harriott, Patrick ;
Mallot, Hanspeter A. .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2007, 561 (1-3) :85-90
[16]   Subcellular and metabolic examination of amyloid-β peptides in Alzheimer disease pathogenesis: Evidence for Aβ25-35 [J].
Kaminsky, Yury G. ;
Marlatt, Michael W. ;
Smith, Mark A. ;
Kosenko, Elena A. .
EXPERIMENTAL NEUROLOGY, 2010, 221 (01) :26-37
[17]   GSK-3β Is Required for Memory Reconsolidation in Adult Brain [J].
Kimura, Tetsuya ;
Yamashita, Shunji ;
Nakao, Shinobu ;
Park, Jung-Mi ;
Murayama, Miyuki ;
Mizoroki, Tatsuya ;
Yoshiike, Yuji ;
Sahara, Naruhiko ;
Takashima, Akihiko .
PLOS ONE, 2008, 3 (10)
[18]   Blockade of NMDA receptors pre-training, but not post-training, impairs object displacement learning in the rat [J].
Larkin, Aoife E. ;
Fahey, Briana ;
Gobbo, Oliviero ;
Callaghan, Charlotte K. ;
Cahill, Emma ;
O'Mara, Shane M. ;
Kelly, Aine M. .
BRAIN RESEARCH, 2008, 1199 :126-132
[19]   Appetitive memory reconsolidation depends upon NMDA receptor-mediated neurotransmission [J].
Lee, Jonathan L. C. ;
Everitt, Barry J. .
NEUROBIOLOGY OF LEARNING AND MEMORY, 2008, 90 (01) :147-154
[20]  
Lenox RH, 2000, J CLIN PSYCHIAT, V61, P5
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