Endoplasmic Reticulum Stress in Bone Metastases

被引：3

作者：

Xu, Longyong ^{[1
,2
,3
]}

Zhang, Weijie ^{[1
,2
,3
]}

Zhang, Xiang H-F ^{[1
,2
,3
]}

Chen, Xi ^{[1
,2
,3
]}

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[2] Baylor Coll Med, Lester & Sue Smith Breast Ctr, Houston, TX 77030 USA

[3] Baylor Coll Med, Dan L Duncan Canc Ctr, Houston, TX 77030 USA

来源：

FRONTIERS IN ONCOLOGY | 2020年 / 10卷

基金：

美国国家卫生研究院;

关键词：

bone metastases; seed and soil; metastatic niche; ER stress; unfolded protein response; immunotherapy; UNFOLDED-PROTEIN-RESPONSE; DISSEMINATED TUMOR-CELLS; TO-MESENCHYMAL TRANSITION; BREAST-CANCER; ER-STRESS; TRANSMEMBRANE PROTEIN; TRANSCRIPTION FACTOR; EARLY DISSEMINATION; PROMOTES SURVIVAL; OSTEOGENIC NICHE;

D O I：

10.3389/fonc.2020.01100

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastases-the spreading of cancer cells from primary tumors to distant organs, including bone-is often incurable and is the major cause of morbidity in cancer patients. Understanding how cancer cells acquire the ability to colonize to bone and become overt metastases is critical to identify new therapeutic targets and develop new therapies against bone metastases. Recent reports indicate that the endoplasmic reticulum (ER) stress and, as its consequence, the unfolded protein response (UPR) is activated during metastatic dissemination. However, their roles in this process remain largely unknown. In this review, we discuss the recent progress on evaluating the tumorigenic, immunoregulatory and metastatic effects of ER stress and the UPR on bone metastases. We explore new opportunities to translate this knowledge into potential therapeutic strategies for patients with bone metastases.

引用

页数：11

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