Adolescent suicide attempts and ideation are linked to brain function during peer interactions

被引:49
作者
Harms, Madeline B. [1 ]
Casement, Melynda D. [2 ]
Teoh, Jia Yuan [3 ]
Ruiz, Sarah [1 ]
Scott, Hannah [3 ]
Wedan, Riley [3 ]
Quevedo, Karina [3 ]
机构
[1] Univ Minnesota, Inst Child Dev, 51 E River Rd, Minneapolis, MN 55455 USA
[2] Univ Oregon, Dept Psychol, Eugene, OR 97403 USA
[3] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA
关键词
Adolescence; Suicide; Social interaction; Neuroimaging; Cyberball; INTERPERSONAL-PSYCHOLOGICAL THEORY; INFERIOR PARIETAL LOBULE; RISK-FACTORS; DEPRESSION; REWARD; SCHIZOPHRENIA; REJECTION; CONNECTIVITY; METAANALYSIS; NEUROSCIENCE;
D O I
10.1016/j.pscychresns.2019.05.001
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Understanding the neural correlates of social interaction among depressed adolescents with suicidal tendencies might help personalize treatment. We tested whether brain function during social interaction is disrupted for depressed adolescents with (1) high suicide ideation and (2) recent attempts. Depressed adolescents with high suicide ideation, including attempters (n = 45;HS) or low suicide ideation (n = 42;LS), and healthy adolescents (n = 39;HC), completed a version of the Cyberball peer interaction task during an fMRI scan. Groups were compared on brain activity during peer exclusion and inclusion versus a non-social condition. During peer exclusion and inclusion, HS youth showed significantly lower activity in precentral and postcentral gyrus, superior temporal gyrus, medial frontal gyrus, insula, and putamen compared to LS youth; and significantly reduced activity in caudate and anterior cingulate cortex compared to HC youth. In a second analysis, suicide attempters (n = 26;SA) were compared to other groups. SA adolescents showed significantly higher activity in ACC and superior and middle frontal gyrus than all other groups. Brain activity was significantly correlated with negative emotionality, social functioning, and cognitive control. Conclusions: Adolescent suicide ideation and attempts were linked to altered neural function during positive and negative peer interactions. We discuss the implications of these findings for suicide prevention efforts.
引用
收藏
页码:1 / 9
页数:9
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