build, operate, maintain, and manage process manufacturing facilities in full concert with the business and manufacturing missions of the enterprise. This paper provides a roadmap for the chemical processing industry, and for the corporations, universities and consortia who endorse the concept of smart process manufacturing to move from today's operations to a future desired state. That future state is defined as a set of research thrusts laid out in pathways, or lanes, that lead to a realization of the vision for SPM.Smart process manufacturing (SPM) refers to a design and operational paradigm involving the integration of measurement and actuation; environment, safety, and health (ES&H) protection; regulatory control; real-time optimization and monitoring; and planning and scheduling. This integrated approach provides the basis for a strong predictive mode of operation with a much swifter incident-response capability. Smart process manufacturing is the enterprise-wide application of "smart" technologies, tools, and systems coupled with knowledge-enabled personnel to plan, design, build, operate, maintain, and manage process manufacturing facilities in full concert with the business and manufacturing missions of the enterprise. This paper provides a roadmap for the chemical processing industry, and for the corporations, universities and consortia who endorse the concept of smart process manufacturing to move from today's operations to a future desired state. That future state is defined as a set of research thrusts laid out in pathways, or lanes, that lead to a realization of the vision for SPM.