Lymphangiogenesis and lymphatic vessel remodelling in cancer

被引：649

作者：

Stacker, Steven A. ^{[1
,2
,3
]}

Williams, Steven P. ^{[1
]}

Karnezis, Tara ^{[1
,2
]}

Shayan, Ramin ^{[1
,3
,4
,5
]}

Fox, Stephen B. ^{[6
]}

Achen, Marc G. ^{[1
,2
,3
]}

机构：

[1] Peter MacCallum Canc Ctr, Tumour Angiogenesis Program, East Melbourne, Vic 3002, Australia

[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic 3010, Australia

[3] Royal Melbourne Hosp, Dept Surg, Parkville, Vic 3050, Australia

[4] Univ Melbourne, St Vincents Hosp, Dept Surg, Fitzroy, Vic 3065, Australia

[5] Australian Catholic Univ, OBrien Inst, Fitzroy, Vic 3065, Australia

[6] Peter MacCallum Canc Ctr, Dept Pathol, East Melbourne, Vic 3002, Australia

来源：

NATURE REVIEWS CANCER | 2014年 / 14卷 / 03期

基金：

英国医学研究理事会;

关键词：

ENDOTHELIAL-GROWTH-FACTOR; CELL LUNG-CANCER; PROMOTES TUMOR-METASTASIS; VEGF-D PROMOTES; VASCULAR NETWORK FORMATION; CHEMOKINE RECEPTOR CXCR4; I COLORECTAL-CARCINOMA; HUMAN BREAST-CANCER; FACTOR-C EXPRESSION; NODE METASTASIS;

D O I：

10.1038/nrc3677

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The generation of new lymphatic vessels through lymphangiogenesis and the remodelling of existing lymphatics are thought to be important steps in cancer metastasis. The past decade has been exciting in terms of research into the molecular and cellular biology of lymphatic vessels in cancer, and it has been shown that the molecular control of tumour lymphangiogenesis has similarities to that of tumour angiogenesis. Nevertheless, there are significant mechanistic differences between these biological processes. We are now developing a greater understanding of the specific roles of distinct lymphatic vessel subtypes in cancer, and this provides opportunities to improve diagnostic and therapeutic approaches that aim to restrict the progression of cancer.

引用

页码：159 / 172

页数：14

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