Chemical Modifications and Biological Activities of Polysaccharides

被引：52

作者：

Huang, Gangliang ^{[1
]}

Chen, Xin ^{[1
]}

Huang, Hualiang ^{[1
,2
]}

机构：

[1] Chongqing Normal Univ, Coll Chem, Chongqing 401331, Peoples R China

[2] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430073, Peoples R China

来源：

CURRENT DRUG TARGETS | 2016年 / 17卷 / 15期

关键词：

Antioxidation effect; antitumor activity; antiviral action; biological activities; chemical modifications; immunoenhancement; polysaccharides; ANTIOXIDANT ACTIVITY; IN-VITRO; SULFATED POLYSACCHARIDES; DENDROBIUM-HUOSHANENSE; ANTIVIRAL ACTIVITY; ANTITUMOR-ACTIVITY; PORIA-COCOS; PHOSPHORYLATION; VIRUS; CARBOXYMETHYLATION;

D O I：

10.2174/1389450117666160502151004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The chemical modifications of polysaccharides involve the use of chemical methods to modify some special structures or functional groups of polysaccharides on the main chains or side chains. The chemical methods include sulfation, phosphorylation, acetylation, carboxymethylation etc. Therefore, spatial structures, and physical and chemical properties of polysaccharides change, which enhance the biological activities of polysaccharides, e.g., immune regulation, antivirus, anti-tumor, anti-oxidation, etc.

引用

页码：1799 / 1803

页数：5

共 35 条

[1] Synthesis and antioxidant activity of phosphorylated polysaccharide from Portulaca oleracea L. with H3PW12O40 immobilized on polyamine functionalized polystyrene bead as catalyst [J].

Chen, Tong ;

Zhu, Ling ;

Liu, Xiaoyan ;

Li, Yuanyuan ;

Zhao, Chuande ;

Xu, Zhigang ;

Yan, Wenfu ;

Zhang, Haixia .

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 2011, 342-43 :74-82

[2] Immunopotentiation and anti-tumor activity of carboxymethylated-sulfated β-(1→3)-D-glucan from Poria cocos [J].

Chen, Xiaoyu ;

Zhang, Lina ;

Cheung, Peter Chi Keung .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2010, 10 (04) :398-405

[3] Chain conformation and anti-tumor activities of phosphorylated (1→3)-β-D-glucan from Poria cocos [J].

Chen, Xiaoyu ;

Xu, Xiaojuan ;

Zhang, Lina ;

Zeng, Fanbo .

CARBOHYDRATE POLYMERS, 2009, 78 (03) :581-587

[4]

Chen XM, 2002, CHINESE J CHEM, V20, P1406

[5] Acetylation and carboxymethylation of the polysaccharide from Ganoderma atrum and their antioxidant and immunomodulating activities [J].

Chen, Yi ;

Zhang, Hui ;

Wang, Yuanxing ;

Nie, Shaoping ;

Li, Chang ;

Xie, Mingyong .

FOOD CHEMISTRY, 2014, 156 :279-288

[6] Comparison of Bush Sophora Root polysaccharide and its sulfate's anti-duck hepatitis A virus activity and mechanism [J].

Chen, Yun ;

Xiong, Wen ;

Zeng, Ling ;

Wang, Deyun ;

Liu, Jiaguo ;

Wu, Yi ;

Hu, Yuanliang .

CARBOHYDRATE POLYMERS, 2014, 102 :333-340

[7] Phosphorylation of Alginate: Synthesis, Characterization, and Evaluation of in Vitro Mineralization Capacity [J].

Coleman, Robert J. ;

Lawrie, Gwen ;

Lambert, Lynette K. ;

Whittaker, Michael ;

Jack, Kevin S. ;

Grondahl, Lisbeth .

BIOMACROMOLECULES, 2011, 12 (04) :889-897

[8] The in vitro antiviral property of Azadirachta indica polysaccharides for poliovirus [J].

Faccin-Galhardi, Ligia Carla ;

Yamamoto, Kristie Aimi ;

Ray, Sayani ;

Ray, Bimalendu ;

Carvalho Linhares, Rosa Elisa ;

Nozawa, Carlos .

JOURNAL OF ETHNOPHARMACOLOGY, 2012, 142 (01) :86-90

[9] Preparation, chain conformation and anti-tumor activities of water-soluble phosphated (1 → 3)-α-D-glucan from Poria cocos mycelia [J].

Huang, Qilin ;

Zhang, Lina .

CARBOHYDRATE POLYMERS, 2011, 83 (03) :1363-1369

[10] Effect of sulfated astragalus polysaccharide on cellular infectivity of infectious bursal disease virus [J].

Huang, Xiaoyan ;

Wang, Deyun ;

Hu, Yuanhang ;

Lu, Yu ;

Guo, Zhenhuan ;

Kong, Xiangfeng ;

Sun, Junfing .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2008, 42 (02) :166-171

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