Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands

被引:26
作者
Meingassner, Josef G. [1 ]
Aschauer, Heinrich [1 ]
Winiski, Anthony P. [1 ]
Dales, Natalie [2 ]
Yowe, David [2 ]
Winther, Michael D. [3 ]
Zhang, Zaihui [3 ]
Stuetz, Anton [1 ]
Billich, Andreas [1 ,4 ]
机构
[1] Novartis Inst BioMed Res, Vienna, Austria
[2] Novartis Inst BioMed Res, Cambridge, MA USA
[3] Xenon Pharmaceut Inc, Burnaby, BC, Canada
[4] Novartis Inst BioMed Res, Basel, Switzerland
关键词
EXPRESSION; GENE; SEBOCYTES;
D O I
10.1038/jid.2013.89
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
引用
收藏
页码:2091 / 2094
页数:4
相关论文
共 11 条
[1]   A Toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria [J].
Georgel, P ;
Crozat, K ;
Lauth, X ;
Makrantonaki, E ;
Seltmann, H ;
Sovath, S ;
Hoebe, K ;
Du, X ;
Rutschmann, S ;
Jiang, ZF ;
Bigby, T ;
Nizet, V ;
Zouboulis, CC ;
Beutler, B .
INFECTION AND IMMUNITY, 2005, 73 (08) :4512-4521
[2]   Expression of lipogenic factors galectin-12, resistin, SREBP-1, and SCD in human sebaceous glands and cultured sebocytes [J].
Harrison, Wesley J. ;
Bull, Jonathan J. ;
Seltmann, Holger ;
Zouboulis, Christos C. ;
Philpott, Michael P. .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 (06) :1309-1317
[3]   Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development [J].
Miyazaki, M ;
Dobrzyn, A ;
Elias, PM ;
Ntambi, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (35) :12501-12506
[4]   Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors [J].
Miyazaki, M ;
Jacobson, MJ ;
Man, WC ;
Cohen, P ;
Asilmaz, E ;
Friedman, JM ;
Ntambi, JM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (36) :33904-33911
[5]   Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid [J].
Miyazaki, M ;
Man, WC ;
Ntambi, JM .
JOURNAL OF NUTRITION, 2001, 131 (09) :2260-2268
[6]   Recent insights into stearoyl-CoA desaturase-1 [J].
Ntambi, JM ;
Miyazaki, M .
CURRENT OPINION IN LIPIDOLOGY, 2003, 14 (03) :255-261
[7]   Asebia-2J (Scd1ab2J):: A new allele and a model for scarring alopecia [J].
Sundberg, JP ;
Boggess, D ;
Sundberg, BA ;
Eilertsen, K ;
Parimoo, S ;
Filippi, M ;
Stenn, K .
AMERICAN JOURNAL OF PATHOLOGY, 2000, 156 (06) :2067-2075
[8]   Discovery of Piperazin-1-ylpyridazine-Based Potent and Selective Stearoyl-CoA Desaturase-1 Inhibitors for the Treatment of Obesity and Metabolic Syndrome [J].
Zhang, Zaihui ;
Sun, Shaoyi ;
Kodumuru, Vishnumurthy ;
Hou, Duanjie ;
Liu, Shifeng ;
Chakka, Nagasree ;
Sviridov, Serguei ;
Chowdhury, Sultan ;
McLaren, David G. ;
Ratkay, Leslie G. ;
Khakh, Kuldip ;
Cheng, Xing ;
Gschwend, Heinz W. ;
Kamboj, Rajender ;
Fu, Jianmin ;
Winther, Michael D. .
JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (02) :568-583
[9]   Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse [J].
Zheng, Y ;
Eilertsen, KJ ;
Ge, L ;
Zhang, L ;
Sundberg, JP ;
Prouty, SM ;
Stenn, KS ;
Parimoo, S .
NATURE GENETICS, 1999, 23 (03) :268-270
[10]   Scd3 -: A novel gene of the stearoyl-CoA desaturase family with restricted expression in skin [J].
Zheng, Y ;
Prouty, SM ;
Harmon, A ;
Sundberg, JP ;
Stenn, KS ;
Parimoo, S .
GENOMICS, 2001, 71 (02) :182-191