A Unified Approach to the Four Azaindoline Families by Inter-/Intramolecular Annulative Diamination of Vinylpyridines

被引：35
作者：
Danneman, Michael W.
Hong, Ki Bum [1 ]
Johnston, Jeffrey N.
机构：
[1] Vanderbilt Univ, Dept Chem, Nashville, TN 37235 USA
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 15期
基金：
美国国家科学基金会;
关键词：
DIELS-ALDER REACTIONS; RADICAL IPSO-SUBSTITUTION; CARBON-FLUORINE BOND; ELECTRON-RICH AMINES; RING-TRANSFORMATIONS; ANNELATED PYRIDINES; ALKENE DIAMINATION; DERIVATIVES; CYCLIZATION; REACTIVITY;
D O I：
10.1021/acs.orglett.5b01783
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An operationally straightforward and metal-free inter-/intramolecular oxidative diamination of vinyl amino-pyridines is a Common gateway to access all four azaindoline heterocycle families. 3-Amino azaindolines are formed by the reaction of ortho-vinyl N-tosyl anilines with election-rich amines, using phenyliododiaceate (PIDA) and an iodide additive.
引用
收藏
页码：3806 / 3809
页数：4
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