Expression and prognostic value of VEGFR-2, PDGFR-β, and c-Met in advanced hepatocellular carcinoma

被引：90
作者：
Chu, Jie Sheng [1 ,2 ]
Ge, Fei Jiao [1 ]
Zhang, Bo [3 ]
Wang, Yan [1 ]
Silvestris, Nicola [4 ]
Liu, Lie Jun [1 ]
Zhao, Chuan Hua [1 ]
Lin, Li [1 ]
Brunetti, Anna Elisabetta [5 ]
Fu, Ya Li [1 ]
Wang, Jun [2 ]
Paradiso, Angelo [5 ]
Xu, Jian Ming [1 ]
机构：
[1] Acad Mil Med Sci, Affiliated Hosp Canc Ctr, Beijing 100071, Peoples R China
[2] Jiujiang Canc Hosp, Dept Oncol, Jiujiang 332000, Jiangxi, Peoples R China
[3] Acad Mil Med Sci, Affiliated Hosp, Dept Pathol, Beijing 100071, Peoples R China
[4] Natl Canc Inst Giovanni Paolo II, Med Oncol Unit, Bari, Italy
[5] Natl Canc Inst Giovanni Paolo II, Sci Direct, I-70124 Bari, Italy
来源：
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2013年 / 32卷
关键词：
Hepatocellular carcinoma; VEGFR-2; PDGFR-beta; c-Met; Survival analysis; Sorafenib; ENDOTHELIAL GROWTH-FACTOR; SORAFENIB; ANGIOGENESIS;
D O I：
10.1186/1756-9966-32-16
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: We explore the clinical and prognostic significance of expression of vascular endothelial growth factor receptor (VEGFR)-2, platelet-derived growth factor receptor (PDGFR)-beta, and c-Met in patients with hepatocellular carcinoma (HCC). Methods: The expression of VEGFR-2, PDGFR-beta, and c-Met were determined by immunohistochemical examination of the tissues of 93 HCC patients. The relationships of these markers with clinicopathological factors and prognosis were then analyzed. Results: High expression of VEGFR-2, PDGFR-beta, and c-Met was found in 86%, 19.4%, and 80.6% of patients, respectively. Expression of VEGFR-2 correlated with gender (P = 0.044), hepatitis B surface antigen positivity (P = 0.024), degree of tumor differentiation (P = 0.023), and hepatic cirrhosis (P = 0.026). Expression of PDGFR-beta correlated with alpha-fetoprotein level (P = 0.029), tumor size (P = 0.033), and hepatic cirrhosis (P = 0.023). No significant correlations were identified between expression of c-Met and clinicopathological factors. Expression of PDGFR-beta correlated with overall survival (P = 0.046) and expression of c-Met correlated with progression-free survival (P = 0.01). Conclusions: We found that in patients with HCC, high expression of VEGFR-2 correlates with chronic hepatitis B virus infection and hepatic cirrhosis. High expression of PDGFR-beta is a predictor of poor prognosis. High expression of C-Met may predict therapeutic effectiveness of sorafenib in HCC patients.
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页数：8
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