Olfactory dysfunction in multiple sclerosis: Relation to longitudinal changes in plaque numbers in central olfactory structures

被引：67

作者：

Doty, RL

Li, C

Mannon, LJ

Yousem, DM

机构：

[1] Univ Penn, Med Ctr, Ctr Smell & Taste, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

[2] Univ Penn, Med Ctr, Dept Radiol, Philadelphia, PA 19104 USA

来源：

NEUROLOGY | 1999年 / 53卷 / 04期

关键词：

olfactory dysfunction; MS; plaque numbers;

D O I：

10.1212/WNL.53.4.880

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Scores on the University of Pennsylvania Smell Identification Test (UPSIT), as well as the numbers of MRI-determined plaques within the inferior frontal and temporal lobes, were obtained on three or four separate occasions in each of five MS patients over an 18- to 20-month period. A close association was observed, longitudinally, between the remission and exacerbation of plaque numbers and UPSIT scores, with more plaques reflecting lower UPSIT scores. These observations further support the hypothesis that olfactory loss in MS is associated with fluctuations in plaque numbers in central olfactory brain regions.

引用

页码：880 / 882

页数：3

共 9 条

[1]

[Anonymous], 1970, Handbook of clinical neurology

[2] QUANTITATIVE MULTIPLE-SCLEROSIS PLAQUE ASSESSMENT WITH MAGNETIC-RESONANCE IMAGING - ITS CORRELATION WITH CLINICAL-PARAMETERS, EVOKED-POTENTIALS, AND INTRA-BLOOD-BRAIN BARRIER IGG SYNTHESIS [J].