Synthesis, Characterization, and Antimicrobial Properties of Sparfloxacin-Mediated Noble Metal Nanoparticles

被引：3

作者：

Nisar, Muhammad ^{[1
]}

Khan, Shujaat Ali ^{[2
]}

Gul, Maryam ^{[2
]}

Rauf, Abdur ^{[3
]}

Zafar, Salman ^{[2
]}

Ramadan, Mohamed Fawzy ^{[4
,5
]}

机构：

[1] Univ Peshawar, Off Res Innovat & Commercializat, Peshawar 25120, Pakistan

[2] Univ Peshawar, Inst Chem Sci, Peshawar 25120, Pakistan

[3] Univ Swabi, Dept Chem, Anbar 23561, Kpk, Pakistan

[4] Umm Al Qura Univ, Sci Res, POB 715, Mecca, Saudi Arabia

[5] Zagazig Univ, Fac Agr, Biochem Dept, Zagazig 44519, Egypt

来源：

JOURNAL OF PURE AND APPLIED MICROBIOLOGY | 2020年 / 14卷 / 03期

关键词：

Sparfloxacin; Silver; Gold; UV-VIS spectroscopy; FTIR; AFM; SEM; Anti-bacterial activity; SILVER NANOPARTICLES; GREEN SYNTHESIS; ANTIBACTERIAL ACTIVITY; GOLD NANOPARTICLES; ANTIOXIDANT; QUINOLONE; BIOSYNTHESIS; EXTRACT;

D O I：

10.22207/JPAM.14.3.17

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The aim of the current research finding was to synthesize, characterize and antibacterial evaluation of sparfloxacin-mediated noble metal nanoparticles. Noble metal [silver (Ag), and gold (Au)] nanoparticles (NPs), mediated with fluoroquinolone, an anti-bacterial drug [Sparfloxacin, (Sp)], was synthesized by a facile and convenient procedure. Formulated Ag-Sp NPs, and Au-Sp NPs exhibited stability against variation in pH, NaCl solution, temperature, and time. The structural topographies of Ag-Sp, and Au-Sp NPs were determined by fourier transform infrared spectroscopy (FTIR), UV-visible spectroscopy (UV-Vis), scanning electron microscopy (SEM) atomic force microscopy (AFM), and energy dispersive X-ray (EDX). UV-Vis revealed the formulation of NPs by showing typical surface Plasmon absorption maxima at 410 nm for Ag-Sp NPs and 555 nm for Au-Sp NPs. The AFM and SEM analysis ascertained stable mono dispersed Ag-Sp NPs and Au-Sp NPs in the size range of 40-50 nm, and 70-80 nm, respectively. Ag-Sp, and Au-Sp NPs exhibited antibacterial traits against Bacillus subtilis, Staphylococcus aureus, and Klebsiella pneumonia, showing a zone of inhibition (ZOI) ranging from 20 +/- 0.98 mm to 24 +/- 0.94 mm (Ag-Sp NPs), and 22 +/- 0.79 mm to 26 +/- 0.92 mm (Au-Sp NPs) at dose of 3 mg/mL.

引用

页码：1789 / 1800

页数：12

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